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SYNTHESIS – Page 5 – EUREKAMOMENTS IN ORGANIC CHEMISTRY

Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012

Total synthesis of artemisinin, WO2012154906  (A1) 15th nov 2012 link at espacenet   http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20121115&CC=WO&NR=2012154906A1&KC=A1 Indiana University Research And Technology Corporation Inventors Cook, Silas; Zhu, Chun-Yin Application number: WO2012US37214 2012 05 10 Priority number(s): US201161484317P 2011 05 10 Oxidative synthesis; Rearrangement synthesis, The present invention provides a method for manufacturing artemisinin and its congeners from cyclohexenone as… Continue reading Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012

A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-­Dioxolanes under Basic Conditions

A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-­Dioxolanes under Basic Conditions Hassner, Alfred; et al Department of Chemistry,Bar-IlanUniversity,Ramat-Gan52900,Israel Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N-hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence… Continue reading A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-­Dioxolanes under Basic Conditions

Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent

Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent Saeed Khodabakhshi Department of Chemistry, Islamic Azad University, Gachsaran Branch, Gachsaran, Iran, Organic Chemistry International Volume 2012 (2012), Article ID 306162, 5 pages doi:10.1155/2012/306162 http://www.hindawi.com/journals/oci/2012/306162/ General Procedure for the Preparation of Coumarin 3 A mixture of phenol 1 (1 mmol), β-ketoesters 2 (1 mmol), and… Continue reading Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent

Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis

Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis (pages 6309–6320) Ângela C. B. Neves, Mário J. F. Calvete, Teresa M. V. D. Pinho e Melo and Mariette M. Pereira Article first published online: 18 SEP 2012 | DOI: 10.1002/ejoc.201200709 The most relevant results relating to the development and use of catalysts supported… Continue reading Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis

Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc

Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead sciences inc Li, Wenjie; De Croos, Philomen; Fandrick, Keith, R.; Gao, Joe, Ju; Haddad, Nizar; Lu, Zhi-Hui; Qu, Bo; Rodriguez, Sonia; Senanayake, Chris, H.; Zhang, Yongda; Tang, Wenjun, PUB 11 OCT 2012, Drug BI-224436   ((Tentative)) GILEAD, under license from BOERINGER   ING, is developing… Continue reading Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc

Visible-light-mediated conversion of alcohols to halides

http://www.nature.com/nchem/journal/v3/n2/full/nchem.949.html Nature chemistry, v3, pg140-145, 2011 DOI:doi:10.1038/nchem.949 The development of new means of activating molecules and bonds for chemical reactions is a fundamental objective for chemists. In this regard, visible-light photoredox catalysis has emerged as a powerful technique for chemoselective activation of chemical bonds under mild reaction conditions. Here, we report a visible-light-mediated photocatalytic alcohol… Continue reading Visible-light-mediated conversion of alcohols to halides

New bactericide derived from Isatin for treating oilfield reinjection water

http://journal.chemistrycentral.com/content/6/1/90/abstract Isatin, an extract from Strobilanthes cusia (Nees) Kuntze, was the base for synthesizing derivatives that were screened for antibacterial activity against oilfield water-borne bacteria. The bacterial groups are sulfate reducing, iron and total. The derivatives were characterized by spectrums and they showed good to moderate activity against sulfate reducing bacteria. New bactericide derived from… Continue reading New bactericide derived from Isatin for treating oilfield reinjection water

Design Concept for High-LUMO-level Fullerene Electron-acceptors for Organic Solar Cells

Chemistry Letters Vol. 41, No. 8 (August, 2012) Design Concept for High-LUMO-level Fullerene Electron-acceptors for Organic Solar Cells by Yutaka Matsuo on pg 754 Department of Chemistry, School of Science, The University of Tokyo  This review article describes design concept, synthesis, and features of fullerene derivatives having high lowest unoccupied molecular orbital (LUMO) levels to… Continue reading Design Concept for High-LUMO-level Fullerene Electron-acceptors for Organic Solar Cells

Development of Heterogeneous Catalysts for the Conversion of Levulinic Acid to γ-Valerolactone

http://onlinelibrary.wiley.com/doi/10.1002/cssc.201200111/abstract Biomass-derived γ-valerolactone (GVL) can be used for manufacturing food, chemicals, and fuels. Numerous hydrogenation catalysts have been developed for the GVL synthesis, with heterogeneous systems arguably the most viable. We discuss current heterogeneous systems, with emphasis on catalyst innovation and development of integrated biomass processing. William R. H. Wright, Regina Palkovits Development of Heterogeneous… Continue reading Development of Heterogeneous Catalysts for the Conversion of Levulinic Acid to γ-Valerolactone