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SYNTHESIS – Page 6 – EUREKAMOMENTS IN ORGANIC CHEMISTRY

2′-Hydroxychalcone to Flavanone: Asymmetric Catalysis

http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200838/abstract Asymmetric Ion-Pairing Catalysis of the Reversible Cyclization of 2′-Hydroxychalcone to Flavanone: Asymmetric Catalysis of an Equilibrating Reaction Lukas Hintermann and Claudia Dittmer    The cyclization of nonactivated 2′-hydroxychalcones to flavanones has been realized for the first time with asymmetric induction. In spite of the reversibility of the reactions, this ion-pairing catalysis reaches intrinsic enantioselectivities… Continue reading 2′-Hydroxychalcone to Flavanone: Asymmetric Catalysis

COLOURFUL MECHANISMS-ACADEMIC HELP

Epoxidation OZONOLYSIS oxidations DIELS ALDER RXN We noted earlier that addition reactions of alkenes often exhibited STEREOSPEFICITY, in that the reagent elements in some cases added syn and in other cases anti to the the plane of the double bond. Both reactants in the Diels-Alder reaction may demonstrate stereoisomerism, and when they do it is… Continue reading COLOURFUL MECHANISMS-ACADEMIC HELP

Efficient levoglucosenone production

Levoglucosenone Levoglucosenone is a highly dehydrated sugar that has been used in the preparation of chiral synthons such as (–)-y-multistriatin and (+)-Prelog—Djerassi lactonic acid. Negative-form is a pyrolysis product of cellulose and cellulose-containing materials including pulp and paper waste products. Known as a pyrolytic product of cellulose, which is very useful as a chiral source… Continue reading Efficient levoglucosenone production

Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes

Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes 很高兴看到来自中国的精彩文章 http://onlinelibrary.wiley.com/doi/10.1002/jccs.201100474/abstract DOI: 10.1002/jccs.201100474 Chiral 8-substituted 2-(8,10,10-trimethyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl)-phenols were prepared from a high enantiopurity (>97% ee) of (1R)-(+)-alpha-pinene, and assessed in the enantioselective addition of diethylzinc to substituted benzaldehydes, giving the (S)-alcohols with enantiomeric excess ranging from 33% to 89%. Interestingly, in all cases,… Continue reading Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes

IMATINIB…..

Medicine for Blood Cancer ‘Imitinef Mercilet’ is a medicine which cures blood cancer. Its available free of cost at “Adyar Cancer Institute in Chennai”. Create Awareness. It might help someone.Cancer   Institute in Adyar, Chennai ‘Imitinef Mercilet’ is apparently an alternative spelling of the drug Imatinib mesylate which is used in the treatment of some… Continue reading IMATINIB…..

Pd-catalyzed coupling reactions of 1,1-dibromo-1-alkenes with various arylboronic acids in Aqueous Solution

Effective Palladium-Catalyzed Synthesis of Triarylethene-Based Molecules in Aqueous Solution Yan Zhu, et al DOI: 10.1002/ejoc.201200577 http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200577/abstract  Highly effective and selective Pd-catalyzed coupling reactions of 1,1-dibromo-1-alkenes with various arylboronic acids have been performed in aqueous solution under mild conditions. The method is simple, economic, and practical for the synthesis of triarylethene-based compounds.     General procedure for… Continue reading Pd-catalyzed coupling reactions of 1,1-dibromo-1-alkenes with various arylboronic acids in Aqueous Solution

SYNTHESIS OF UGI ADDUCT

  To synthesize a Ugi aduct from Benzaldehyde, Furfuryl amine, Benzylisocyanide and BOC-GLY-OH in methanol using Ugi 4Component Reaction. BOC-GLY-OH,  STR IS Procedure A solution of Benzaldehyde (212 uL, 2.09 mmol) and Furfuryl amine (FFA) (235uL, 2.66 mmol )was prepared in methanol-d4 in a 4mL volumetric flask to form an imine overnight. The next day a solution of BOC-GLY-OH(350 mg, 1.99 mmol), andBenzylisocyanide (240uL,… Continue reading SYNTHESIS OF UGI ADDUCT