Cubane[1] Pentacyclo[4.2.0.02,5.03,8.04,7]octane CAS 277-10-1 Cubane (C8H8) is a synthetic hydrocarbon molecule that consists of eight carbon atoms arranged at the corners of a cube, with one hydrogen atom attached to each carbon atom. A solid crystalline substance, cubane is one of the Platonic hydrocarbons. It was first synthesized in 1964 by Philip Eaton, a professor of chemistry at the University of Chicago.[2] Before Eaton and Cole’s work, researchers believed that… Continue reading The Magic of Cubane!
Category: SYNTHESIS
Synthesis of Azadirachtin
Azadirachtin 11141-17-6 cas no Azadirachtin, a chemical compound belonging to the limonoid group, is asecondary metabolite present in neem seeds. It is a highly oxidizedtetranortriterpenoid which boasts a plethora of oxygen functionality, comprising an enol ether, acetal, hemiacetal, and tetra-substituted oxirane as well as a variety of carboxylic esters. This compound is a tetraterpenoid characteristic of the Meliaceae family but particularly from the Neem tree (A. indica), indigenous to… Continue reading Synthesis of Azadirachtin
Whisky lactone
Whisky Lactone Whisky lactone, also known as β-methyl-γ-octalactone or quercus lactone (from the Latin for oak treeQuercus alba), is a flavouring found in American bourbon whiskies, and is also found in all types of oak. The flavour gets into the whisky when it’s matured in oak barrels. The pure molecule has a fierce, strong, and sweet smell… Continue reading Whisky lactone
Amide Hydrogenation in Flow Reactor
http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html Amide Hydrogenation in Flow Reactor (wiley) Amines are produced by amide hydrogenation over a bimetallic platinum–rhenium catalyst in a high-throughput vertical flow reactor Read more http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html
Transition-metal-catalyzed C–C bond formation through the fixation ofcarbon dioxide
Carbon dioxide is an important carbon source in the atmosphere and is “problematic” toward the activities of human beings. Although carbon dioxide is a cheap, abundant and relatively nontoxic C1 source, its chemical transformations have not been widely developed so far and are still far from synthetic applications, especially in the construction of the C–C… Continue reading Transition-metal-catalyzed C–C bond formation through the fixation ofcarbon dioxide
GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions
Green Chem., 2013, Advance Article DOI: 10.1039/C3GC41799A, Communication Huiyan Wang, Xuecheng Liu, Xian Feng, Zhibin Huang, Daqing Shi This synthesis was confirmed to follow the GAP chemistry process, which can avoid traditional chromatography and recrystallization purification methods. GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions http://pubs.rsc.org/en/Content/ArticleLanding/2013/GC/C3GC41799A?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract Huiyan Wang,ab Xuecheng Liu,a Xian… Continue reading GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions
Lewis acid-surfactant-combined catalyzed synthesis of 4-aminocyclopentenones from glycals in water
Green Chem., 2013, 15,3180-3183 DOI: 10.1039/C3GC41032C, Communication Siming Wang, Ronny William, Kim Kui Georgina Estelle Seah, Xue-Wei Liu Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 Water makes the difference: an example of the Lewis acid-surfactant-combined catalyzed synthesis of biologically significant 4-aminocyclopentenones was developed.… Continue reading Lewis acid-surfactant-combined catalyzed synthesis of 4-aminocyclopentenones from glycals in water
Axial-to-central chirality transfer in cyclization processes
Axial-to-central chirality transfer in cyclization processes Substrates, bearing axial chirality, can cyclize intra- or inter-molecularly with concomitant transfer of axial-to-central chirality to produce at least one stereocenter. In order to satisfy a strict definition of axial-to-central chirality transfer, the initial axial chirality must be lost during the cyclization process. Highly functionalized enantiopure carbocycles and heterocycles… Continue reading Axial-to-central chirality transfer in cyclization processes
An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature
An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature Green Chem., 2013, Advance Article DOI: 10.1039/C3GC41469H, Paper Guodong Ding, Weitao Wang, Tao Jiang, Buxing Han The Pd/bentonite catalyst prepared by a simple impregnation method in water is very active and stable for the Suzuki-Miyaura reaction. http://pubs.rsc.org/en/Content/ArticleLanding/2013/GC/C3GC41469H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract Clays, which are nontoxic, abundant, and… Continue reading An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature
Seeding removes barrier to curious cocrystal
Once the heteronuclear seeds had been used in the lab, the cocrystal formed regardless of whether or not the seeds were used The caffeine•benzoic acid cocrystal that has eluded scientists for 60 years has finally been crystallised Cocrystals are crystalline materials composed of two or more molecules held together within the same crystal lattice. Cocrystallisation… Continue reading Seeding removes barrier to curious cocrystal