The Pinnick oxidation is also known as Lindgren oxidation. It is an organic reaction by which aldehydes can be oxidized into its corresponding carboxylic acid, originally developed by Lindgren and Nilsson.ref1 The typical reaction condition used today was modified by G. A. Kraus even before Pinnick.ref2,3 Pinnick proved this condition as general. There are number of ways to oxidize the aldehydes however, only… Continue reading Pinnick oxidation
Category: SYNTHESIS
Sucampo and Abbott Announce Launch of AMITIZA in Japan, 26 nov 2012
Sucampo and Abbott Announce Launch of AMITIZA in Japan Product is Japan’s Only Prescription Medicine for Chronic Constipation Lubiprostone CAS number 136790-76-6 Sucampo Pharmaceuticals, Inc. and Abbott today announced the availability of AMITIZA® (lubiprostone) in Japan, a prescription medicine for the treatment of chronic constipation not caused by organic diseases. AMITIZA was approved by the Ministry of Health,… Continue reading Sucampo and Abbott Announce Launch of AMITIZA in Japan, 26 nov 2012
Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012
Total synthesis of artemisinin, WO2012154906 (A1) 15th nov 2012 link at espacenet http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20121115&CC=WO&NR=2012154906A1&KC=A1 Indiana University Research And Technology Corporation Inventors Cook, Silas; Zhu, Chun-Yin Application number: WO2012US37214 2012 05 10 Priority number(s): US201161484317P 2011 05 10 Oxidative synthesis; Rearrangement synthesis, The present invention provides a method for manufacturing artemisinin and its congeners from cyclohexenone as… Continue reading Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012
A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions
A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions Hassner, Alfred; et al Department of Chemistry,Bar-IlanUniversity,Ramat-Gan52900,Israel Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N-hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence… Continue reading A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions
Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent
Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent Saeed Khodabakhshi Department of Chemistry, Islamic Azad University, Gachsaran Branch, Gachsaran, Iran, Organic Chemistry International Volume 2012 (2012), Article ID 306162, 5 pages doi:10.1155/2012/306162 http://www.hindawi.com/journals/oci/2012/306162/ General Procedure for the Preparation of Coumarin 3 A mixture of phenol 1 (1 mmol), β-ketoesters 2 (1 mmol), and… Continue reading Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent
Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis
Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis (pages 6309–6320) Ângela C. B. Neves, Mário J. F. Calvete, Teresa M. V. D. Pinho e Melo and Mariette M. Pereira Article first published online: 18 SEP 2012 | DOI: 10.1002/ejoc.201200709 The most relevant results relating to the development and use of catalysts supported… Continue reading Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis
Luche reduction
Luche reduction is the selective organic reduction of ketones to alcohols with lanthanoid chlorides such as cerium(III chloride andsodium borohydride. The Luche reduction can be conducted chemoselectively toward ketone in the presence of aldehyde or toward α,β-unsaturated ketone in the presence of non-conjugated ketone.1,2,,3 An enone forms an allyl alcohol in a 1,2-addition. Competing conjugate 1,4-addition is suppressed. The solvent is an alcohol such asmethanol or ethanol. The selectivity can be explained in terms of HSAB theory: carbonyl groups require hard nucleophiles for 1,2-addition. The… Continue reading Luche reduction
Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc
Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead sciences inc Li, Wenjie; De Croos, Philomen; Fandrick, Keith, R.; Gao, Joe, Ju; Haddad, Nizar; Lu, Zhi-Hui; Qu, Bo; Rodriguez, Sonia; Senanayake, Chris, H.; Zhang, Yongda; Tang, Wenjun, PUB 11 OCT 2012, Drug BI-224436 ((Tentative)) GILEAD, under license from BOERINGER ING, is developing… Continue reading Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc
REVIEW–AMIIDE BOND
http://www.nature.com/nature/journal/v480/n7378/full/nature10702.html#/f3 One of the most important reactions in organic chemistry—amide bond formation—is often overlooked as a contemporary challenge because of the widespread occurrence of amides in modern pharmaceuticals and biologically active compounds. But existing methods are reaching their inherent limits, and concerns about their waste and expense are becoming sharper. Novel chemical approaches to amide… Continue reading REVIEW–AMIIDE BOND
Visible-light-mediated conversion of alcohols to halides
http://www.nature.com/nchem/journal/v3/n2/full/nchem.949.html Nature chemistry, v3, pg140-145, 2011 DOI:doi:10.1038/nchem.949 The development of new means of activating molecules and bonds for chemical reactions is a fundamental objective for chemists. In this regard, visible-light photoredox catalysis has emerged as a powerful technique for chemoselective activation of chemical bonds under mild reaction conditions. Here, we report a visible-light-mediated photocatalytic alcohol… Continue reading Visible-light-mediated conversion of alcohols to halides