Category: ORGANIC CHEMISTRY

Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis

Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis (pages 6309–6320) Ângela C. B. Neves, Mário J. F. Calvete, Teresa M. V. D. Pinho e Melo and Mariette M. Pereira Article first published online: 18 SEP 2012 | DOI: 10.1002/ejoc.201200709 The most relevant results relating to the development and use of catalysts supported… Continue reading Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis

Luche reduction

Luche reduction is the selective organic reduction of ketones to alcohols with lanthanoid chlorides such as cerium(III chloride andsodium borohydride. The Luche reduction can be conducted chemoselectively toward ketone in the presence of aldehyde or toward α,β-unsaturated ketone in the presence of non-conjugated ketone.1,2,,3 An enone forms an allyl alcohol in a 1,2-addition. Competing conjugate 1,4-addition is suppressed. The solvent is an alcohol such asmethanol or ethanol. The selectivity can be explained in terms of HSAB theory: carbonyl groups require hard nucleophiles for 1,2-addition. The… Continue reading Luche reduction

Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc

Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead sciences inc Li, Wenjie; De Croos, Philomen; Fandrick, Keith, R.; Gao, Joe, Ju; Haddad, Nizar; Lu, Zhi-Hui; Qu, Bo; Rodriguez, Sonia; Senanayake, Chris, H.; Zhang, Yongda; Tang, Wenjun, PUB 11 OCT 2012, Drug BI-224436   ((Tentative)) GILEAD, under license from BOERINGER   ING, is developing… Continue reading Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc

Dehydration of Carbohydrates to 5-Hydroxymethylfurfural in Ionic Liquids Catalyzed by Hexachlorotriphosphazene

  Dehydration of Carbohydrates to 5-Hydroxymethylfurfural in Ionic Liquids Catalyzed by Hexachlorotriphosphazene (pages 2079–2084)http://onlinelibrary.wiley.com/doi/10.1002/cjoc.201200691/abstractJinliang Song, Binbin Zhang, Jinghua Shi, Jun Ma, Guanying Yang and Buxing Han Article first published online: 25 SEP 2012 | DOI: 10.1002/cjoc.201200691 Highly efficient synthesis of 5-hydroxymethylfurfural (HMF) by dehydration of carbohydrates was catalyzed by hexachlorotriphosphazene (N3P3Cl6) in ionic liquids. Development of… Continue reading Dehydration of Carbohydrates to 5-Hydroxymethylfurfural in Ionic Liquids Catalyzed by Hexachlorotriphosphazene

Starch as a replacement for urea-formaldehyde in medium density fibreboard

Thermoplastic starch can be used to bind wood flour to produce a fibreboards which are mouldable, recyclable and ultimately compostable.   Medium density fibreboard (MDF) is a ubiquitous product formed from wood flour and a formaldehyde-based resin. The use of the latter component causes some health and environmental concerns and its use is restricted. The… Continue reading Starch as a replacement for urea-formaldehyde in medium density fibreboard

REVIEW–AMIIDE BOND

http://www.nature.com/nature/journal/v480/n7378/full/nature10702.html#/f3 One of the most important reactions in organic chemistry—amide bond formation—is often overlooked as a contemporary challenge because of the widespread occurrence of amides in modern pharmaceuticals and biologically active compounds. But existing methods are reaching their inherent limits, and concerns about their waste and expense are becoming sharper. Novel chemical approaches to amide… Continue reading REVIEW–AMIIDE BOND

Visible-light-mediated conversion of alcohols to halides

http://www.nature.com/nchem/journal/v3/n2/full/nchem.949.html Nature chemistry, v3, pg140-145, 2011 DOI:doi:10.1038/nchem.949 The development of new means of activating molecules and bonds for chemical reactions is a fundamental objective for chemists. In this regard, visible-light photoredox catalysis has emerged as a powerful technique for chemoselective activation of chemical bonds under mild reaction conditions. Here, we report a visible-light-mediated photocatalytic alcohol… Continue reading Visible-light-mediated conversion of alcohols to halides

2D-NMR (HMQC, HMBC, 1H-1H COSY and NOESY), for rel- (1R,2S,3R,4R) p-menthane-1,2,3-triol 3-O-β-D-glucopyranoside (1)

http://journal.chemistrycentral.com/content/6/1/37 New monocyclic monoterpenoid glycoside from Mentha haplocalyx Briq. Gai-Mei Sheet al Chemistry Central Journal 2012, 6:37 doi:10.1186/1752-153X-6-37 new monocyclic monoterpenoid glycosides, rel-(1R,2S,3R,4R) p-menthane-1,2,3-triol 3-O-β-D-glucopyranoside (1) were isolated from aqueous acetone extract of the aerial parts of Mentha haplocalyx Briq.. On the basis of spectroscopic methods, including 2D-NMR (HMQC, HMBC, 1H-1H COSY and NOESY), the… Continue reading 2D-NMR (HMQC, HMBC, 1H-1H COSY and NOESY), for rel- (1R,2S,3R,4R) p-menthane-1,2,3-triol 3-O-β-D-glucopyranoside (1)

New bactericide derived from Isatin for treating oilfield reinjection water

http://journal.chemistrycentral.com/content/6/1/90/abstract Isatin, an extract from Strobilanthes cusia (Nees) Kuntze, was the base for synthesizing derivatives that were screened for antibacterial activity against oilfield water-borne bacteria. The bacterial groups are sulfate reducing, iron and total. The derivatives were characterized by spectrums and they showed good to moderate activity against sulfate reducing bacteria. New bactericide derived from… Continue reading New bactericide derived from Isatin for treating oilfield reinjection water