Deprecated: Return type of Endurance_Collection::offsetExists($key) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 418

Deprecated: Return type of Endurance_Collection::offsetGet($key) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 429

Deprecated: Return type of Endurance_Collection::offsetSet($key, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 439

Deprecated: Return type of Endurance_Collection::offsetUnset($key) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 452

Deprecated: Return type of Endurance_Collection::count() should either be compatible with Countable::count(): int, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 82

Deprecated: Return type of Endurance_Collection::getIterator() should either be compatible with IteratorAggregate::getIterator(): Traversable, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 219
DR ANTHONY MELVIN CRASTO Ph.D – Page 17 – EUREKAMOMENTS IN ORGANIC CHEMISTRY

Author: DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D,( ICT), Worlddrugtracker, Helping millions with chemistry sites, million hits on google

COLOURFUL MECHANISMS-ACADEMIC HELP

Epoxidation OZONOLYSIS oxidations DIELS ALDER RXN We noted earlier that addition reactions of alkenes often exhibited STEREOSPEFICITY, in that the reagent elements in some cases added syn and in other cases anti to the the plane of the double bond. Both reactants in the Diels-Alder reaction may demonstrate stereoisomerism, and when they do it is… Continue reading COLOURFUL MECHANISMS-ACADEMIC HELP

Cram’s rule

The Cram’s rule of asymmetric induction developed by Donald J. Cram in 1952,  is an early concept relating to the prediction of stereochemistry in certain acyclic systems. In full the rule is: In certain non-catalytic reactions that diastereomer will predominate, which could be formed by the approach of the entering group from the least hindered side… Continue reading Cram’s rule

Efficient levoglucosenone production

Levoglucosenone Levoglucosenone is a highly dehydrated sugar that has been used in the preparation of chiral synthons such as (–)-y-multistriatin and (+)-Prelog—Djerassi lactonic acid. Negative-form is a pyrolysis product of cellulose and cellulose-containing materials including pulp and paper waste products. Known as a pyrolytic product of cellulose, which is very useful as a chiral source… Continue reading Efficient levoglucosenone production

Isolation of Optically Pure (S)-(+)-Ibuprofen

Isolation of Optically Pure (S)-(+)-Ibuprofen In this laboratory exercise we will isolate (S)-(+)-Ibuprofen from a racemic mixture of both enantiomers of this compound. This will be accomplished by treating the racemic mixture of Ibuprofen with (S)-(-)-alpha-Phenethylamine, whose molecules are themselves chiral, to form (S,S) and (R,S) Ibuprofen/Phenethylamine diastereomeric salts. Because the (S,S) salt is much… Continue reading Isolation of Optically Pure (S)-(+)-Ibuprofen

Resolution-Racemization-Recycle.

In one of its steps the racemic alcohol 1 is dissolved in a mixture of toluene and methanol to which solution is added optically active (S)-mandelic acid 3. The alcohol (S)-enantiomer forms an insoluble diastereomeric salt with the mandelic acid and can be filtered from the solution. Simple deprotonation with sodium hydroxide liberates free (S)-alcohol. In the meanwhile the (R)-alcohol remains in solution unaffected and is recycled back… Continue reading Resolution-Racemization-Recycle.

Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes

Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes 很高兴看到来自中国的精彩文章 http://onlinelibrary.wiley.com/doi/10.1002/jccs.201100474/abstract DOI: 10.1002/jccs.201100474 Chiral 8-substituted 2-(8,10,10-trimethyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl)-phenols were prepared from a high enantiopurity (>97% ee) of (1R)-(+)-alpha-pinene, and assessed in the enantioselective addition of diethylzinc to substituted benzaldehydes, giving the (S)-alcohols with enantiomeric excess ranging from 33% to 89%. Interestingly, in all cases,… Continue reading Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes

IMATINIB…..

Medicine for Blood Cancer ‘Imitinef Mercilet’ is a medicine which cures blood cancer. Its available free of cost at “Adyar Cancer Institute in Chennai”. Create Awareness. It might help someone.Cancer   Institute in Adyar, Chennai ‘Imitinef Mercilet’ is apparently an alternative spelling of the drug Imatinib mesylate which is used in the treatment of some… Continue reading IMATINIB…..