DR ANTHONY MELVIN CRASTO Ph.D

Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide)

Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide) Sanofi announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending the approval of once-daily Lyxumia® (lixisenatide) for the treatment of adults with type 2 diabetes mellitus to… Continue reading Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide)

A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions

A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions Hassner, Alfred; et al Department of Chemistry,Bar-IlanUniversity,Ramat-Gan52900,Israel Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N-hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence… Continue reading A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions

IONIC LIQUIDS, USES

Ionic liquids are very popular materials and they enjoy a plethora of applications in various domains of physical sciences. For example, they are used as “solvents” for organic, organometallic syntheses and catalysis, as electrolytes in electrochemistry, in fuel and solar cells, as lubricants, as a stationary phase for chromatography, as matrices for mass spectrometry,… Continue reading IONIC LIQUIDS, USES

Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent

Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent Saeed Khodabakhshi Department of Chemistry, Islamic Azad University, Gachsaran Branch, Gachsaran, Iran, Organic Chemistry International Volume 2012 (2012), Article ID 306162, 5 pages doi:10.1155/2012/306162 http://www.hindawi.com/journals/oci/2012/306162/ General Procedure for the Preparation of Coumarin 3 A mixture of phenol 1 (1 mmol), β-ketoesters 2 (1 mmol), and… Continue reading Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent

A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS

https://docs.google.com/viewer?url=http%3A%2F%2Fwww.mjcce.org.mk%2FPDF%2F28_2_425.pdf A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS Arpita Dugar, Anil Kumar, Rameshwar Ameta, Suresh C. AmetaMACEDONIAN JOURNAL OF CHEM AND CHEM ENG, 2009, V28,2, PG 163 Photochemical aromatic nitration of phenol and salicylic acid has been carried out in the presence of UV radiations and formation of products has been observed spectrophotometrically.… Continue reading A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS

Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis

Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis (pages 6309–6320) Ângela C. B. Neves, Mário J. F. Calvete, Teresa M. V. D. Pinho e Melo and Mariette M. Pereira Article first published online: 18 SEP 2012 | DOI: 10.1002/ejoc.201200709 The most relevant results relating to the development and use of catalysts supported… Continue reading Immobilized Catalysts for Hydroformylation Reactions: A Versatile Tool for Aldehyde Synthesis

Luche reduction

Luche reduction is the selective organic reduction of ketones to alcohols with lanthanoid chlorides such as cerium(III chloride andsodium borohydride. The Luche reduction can be conducted chemoselectively toward ketone in the presence of aldehyde or toward α,β-unsaturated ketone in the presence of non-conjugated ketone.1,2,,3 An enone forms an allyl alcohol in a 1,2-addition. Competing conjugate 1,4-addition is suppressed. The solvent is an alcohol such asmethanol or ethanol. The selectivity can be explained in terms of HSAB theory: carbonyl groups require hard nucleophiles for 1,2-addition. The… Continue reading Luche reduction

Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc

Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead sciences inc Li, Wenjie; De Croos, Philomen; Fandrick, Keith, R.; Gao, Joe, Ju; Haddad, Nizar; Lu, Zhi-Hui; Qu, Bo; Rodriguez, Sonia; Senanayake, Chris, H.; Zhang, Yongda; Tang, Wenjun, PUB 11 OCT 2012, Drug BI-224436 ((Tentative)) GILEAD, under license from BOERINGER ING, is developing… Continue reading Process for the preparation of an HIV integrase inhibitor, WO-2012138670, Gilead Sciences Inc

Dehydration of Carbohydrates to 5-Hydroxymethylfurfural in Ionic Liquids Catalyzed by Hexachlorotriphosphazene

Dehydration of Carbohydrates to 5-Hydroxymethylfurfural in Ionic Liquids Catalyzed by Hexachlorotriphosphazene (pages 2079–2084)http://onlinelibrary.wiley.com/doi/10.1002/cjoc.201200691/abstractJinliang Song, Binbin Zhang, Jinghua Shi, Jun Ma, Guanying Yang and Buxing Han Article first published online: 25 SEP 2012 | DOI: 10.1002/cjoc.201200691 Highly efficient synthesis of 5-hydroxymethylfurfural (HMF) by dehydration of carbohydrates was catalyzed by hexachlorotriphosphazene (N3P3Cl6) in ionic liquids. Development of… Continue reading Dehydration of Carbohydrates to 5-Hydroxymethylfurfural in Ionic Liquids Catalyzed by Hexachlorotriphosphazene

Starch as a replacement for urea-formaldehyde in medium density fibreboard

Thermoplastic starch can be used to bind wood flour to produce a fibreboards which are mouldable, recyclable and ultimately compostable. Medium density fibreboard (MDF) is a ubiquitous product formed from wood flour and a formaldehyde-based resin. The use of the latter component causes some health and environmental concerns and its use is restricted. The… Continue reading Starch as a replacement for urea-formaldehyde in medium density fibreboard