DR ANTHONY MELVIN CRASTO Ph.D

Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides

Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides http://www.publish.csiro.au/nid/51/paper/CH12426.htm Bo Shen and Timothy F. Jamison Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Australian Journal of Chemistry – http://dx.doi.org/10.1071/CH12426 Published online: 19 November 2012 http://www.publish.csiro.au/nid/51/paper/CH12426.htm With the development of a new photochemical flow reactor, a multi-step sequence in… Continue reading Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides

Bedaquiline(Sirturo, TMC207 or R207910) FDA approves 1st new tuberculosis drug in 40 years

(1R,2S)-1-(6-Bromo-2-methoxy-3-quinolyl)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol, cas no 654653-81-3 Bedaquiline FDA approves 1st new tuberculosis drug in 40 years The Food and Drug Administration on Monday approved a Johnson & Johnson tuberculosis drug that is the first new medicine to fight the deadly infection in more than four decades. Bedaquiline (also known as Sirturo, TMC207 or R207910) is an diarylquinoline anti-tuberculosis drug, which was discovered… Continue reading Bedaquiline(Sirturo, TMC207 or R207910) FDA approves 1st new tuberculosis drug in 40 years

LM11A-31, New drug can help paralyzed people walk again

LM11A-31, C12 H25 N3 O2, Pentanamide, 2-amino-3-methyl-N–[2-(4-morpholinyl)ethyl]– WO 2010102212 TO LONGO FRANK, PUB 10.09.2010 THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL PATENT LINK http://patentscope.wipo.int/search/en/WO2010102212 Scientists have developed a pill which they claim could help paralyzed people walk again. The new drug allowed mice with no movement in their lower limbs to walk… Continue reading LM11A-31, New drug can help paralyzed people walk again

Synthesis of vitamin E

The α-tocopherol form of vitamin E Vitamin E refers to a group of eight fat-soluble compounds that include both tocopherolsand tocotrienols.[1] There are many different forms of vitamin E, of which γ-tocopherol is the most common in the North American diet.[2] γ-Tocopherol can be found in corn oil, soybean oil, margarine and dressings.[3][4] In the North American diet, α-Tocopherol, the most biologically active form… Continue reading Synthesis of vitamin E

Facile Synthesis of Benzaldehyde-Functionalized Ionic Liquids and Their Flexible Functional Group Transformations

Facile Synthesis of Benzaldehyde-Functionalized Ionic Liquids and Their Flexible Functional Group Transformations http://www.hindawi.com/journals/oci/2012/208128/ Organic Chemistry International Volume 2012 (2012), Article ID 208128, 5 pages doi:10.1155/2012/208128 Qiang Huang and Baozhong Zheng Department of Materials Science and Engineering, Yunnan University, Kunming 650091, China Three benzaldehyde-functionalized ionic liquids were readily synthesized by quaternization of N-alkylimidazole with benzaldehyde-functionalized alkyl bromides under microwave irradiation… Continue reading Facile Synthesis of Benzaldehyde-Functionalized Ionic Liquids and Their Flexible Functional Group Transformations

Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

organic chemistry international, v 2012 Volume 2012 (2012), doi:10.1155/2012/289023 Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions F. Aneesa,1 K. C. Rajanna,2 Y. Arun Kumar,1 and M. Arifuddin3 1Department of Chemistry, Muffakham Jah College of Engineering and Technology, Mount Pleasant, Banjara Hills, Hyderabad 500034, India 2Department of Chemistry, Osmania University, Hyderabad 500007, India 3National… Continue reading Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

The Formal Total Synthesis of FR252921 – An Immunosuppressant

The Formal Total Synthesis of FR252921 – An Immunosuppressant European Journal of Organic Chemistry Volume 2013, Issue 2, pages 376–388, January 2013 J. S. Yadav and Sandip Sengupta Article first published online: 15 NOV 2012 | DOI: 10.1002/ejoc.201201097 http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201201097/abstract The formal total synthesis of FR252921 is described. The key steps include the preparation of… Continue reading The Formal Total Synthesis of FR252921 – An Immunosuppressant

CES as an Efficient Natural Catalyst for Syn of Schiff Bases under Solvent-Free Conditions: An Innovative Green Approach

CES (calcined eggshell) Organic Chemistry International, Volume 2012 (2012), doi:10.1155/2012/153159 CES as an Efficient Natural Catalyst for Synthesis of Schiff Bases under Solvent-Free Conditions: An Innovative Green Approach Suresh Patil, S. D. Jadhav, and S. K. Shinde Organic Research Laboratory, Department of Chemistry, Padmabhushan Dr. Vasantraodada Patil College, Sangli District, Tasgaon 416312, India http://www.hindawi.com/journals/oci/2012/153159/61695452/ A mild and… Continue reading CES as an Efficient Natural Catalyst for Syn of Schiff Bases under Solvent-Free Conditions: An Innovative Green Approach

One-Pot Synthesis of Alkyl Styryl Sulfides Free from Transition Metal/Ligand Catalyst and Thiols

One-Pot Synthesis of Alkyl Styryl Sulfides Free from Transition Metal/Ligand Catalyst and Thiols http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201201163/abstract European Journal of Organic Chemistry Early View (Online Version of Record published before inclusion in an issue) Adrián A. Heredia and Alicia B. Peñéñory Article first published online: 19 DEC 2012 | DOI: 10.1002/ejoc.201201163 They have developed a one-pot methodology for the… Continue reading One-Pot Synthesis of Alkyl Styryl Sulfides Free from Transition Metal/Ligand Catalyst and Thiols

Total Synthesis and Structure Confirmation of Cryptocaryol A

Total Synthesis and Structure Confirmation of Cryptocaryol A European journal of chemistryEarly View (Online Version of Record published before inclusion in an issue) D. Srinivas Reddy and Debendra K. Mohapatra Article first published online: 19 DEC 2012 | DOI: 10.1002/ejoc.201201309 Maruoka asymmetric allylation, chelation-controlled 1,3-induced allylation, iterative iodocyclization and ring-closing metathesis reactions were used sequentially… Continue reading Total Synthesis and Structure Confirmation of Cryptocaryol A