Tag: DRUGS

Breast Cancer Drugs in Late-Stage Development/Recently Approved

  The article is 2012-2013 based and reader discretion is sought to ascertian the stage of approval Breast Cancer Drugs in Late-Stage Development/Recently Approved   Afinitor® (everolimus) http://newdrugapprovals.wordpress.com/2013/04/27/drug-spotlight-afinitor-everolimus-novartis/ Sponsor: Novartis Method of Action: Mammalian target of rapamycin (mTOR) inhibitor Indications/Phase of Trial: Hepatocellular carcinoma; human epidermal growth factor receptor 2-positive (HER2+) breast cancer first-line and second-line; lymphoma; nonfunctional carcinoid… Continue reading Breast Cancer Drugs in Late-Stage Development/Recently Approved

Amide Hydrogenation in Flow Reactor

http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html Amide Hydrogenation in Flow Reactor (wiley) Amines are produced by amide hydrogenation over a bimetallic platinum–rhenium catalyst in a high-throughput vertical flow reactor Read more http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html

Green N-Methylation of Electron Deficient Pyrroles with Dimethylcarbonate

The N-methylation of electron-deficient pyrroles was affected using dimethyl carbonate in the presence of DMF and catalytic DABCO. This alkylation methodology has proven useful for the alkylation of a variety of pyrroles in 72−98% yields and is considered to be greenchemistry relative to the more common use of methyl halides or dimethyl sulfate. Michael L. Laurila , Nicholas A.… Continue reading Green N-Methylation of Electron Deficient Pyrroles with Dimethylcarbonate

Article On Alternative Solvents:  Shades of Green

The use of alternative reaction solvents is reviewed in terms of life cycle. Supercritical CO2, ionic liquids, fluorous solvents, water, and renewable organics are compared on the basis of their solvency, ease of use, reusability, health and safety, environmental impact, and economic cost. James H. Clark * and Stewart J. Tavener Green Chemistry Centre, Department of Chemistry, University… Continue reading Article On Alternative Solvents:  Shades of Green

RABEPRAZOLE

Pariprazole sodium;Rabeprazole sodium;LY-307640;E-3810;Aciphex;Pariet Rabeprazole /ˌræ.ˈbɛp.ræ.zɔːl/ is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as the sodium salt under the brand names AcipHex (/ˈæsɨfɛks/, referring to pH) in the US, Pariet in Europe, Brazil, Canada, Japan, Russia and Australia, Acigard, Cyra, Rabium, Esoon,Orporo, Parit, Rabemac, Rabiloz, Razo, Rabifast, Rablet and Rabsiv in India, and Zechin in… Continue reading RABEPRAZOLE

Axial-to-central chirality transfer in cyclization processes

Axial-to-central chirality transfer in cyclization processes Substrates, bearing axial chirality, can cyclize intra- or inter-molecularly with concomitant transfer of axial-to-central chirality to produce at least one stereocenter. In order to satisfy a strict definition of axial-to-central chirality transfer, the initial axial chirality must be lost during the cyclization process. Highly functionalized enantiopure carbocycles and heterocycles… Continue reading Axial-to-central chirality transfer in cyclization processes

An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature

An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature Green Chem., 2013, Advance Article DOI: 10.1039/C3GC41469H, Paper Guodong Ding, Weitao Wang, Tao Jiang, Buxing Han The Pd/bentonite catalyst prepared by a simple impregnation method in water is very active and stable for the Suzuki-Miyaura reaction. http://pubs.rsc.org/en/Content/ArticleLanding/2013/GC/C3GC41469H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract Clays, which are nontoxic, abundant, and… Continue reading An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature

Seeding removes barrier to curious cocrystal

Once the heteronuclear seeds had been used in the lab, the cocrystal formed regardless of whether or not the seeds were used The caffeine•benzoic acid cocrystal that has eluded scientists for 60 years has finally been crystallised Cocrystals are crystalline materials composed of two or more molecules held together within the same crystal lattice. Cocrystallisation… Continue reading Seeding removes barrier to curious cocrystal