Tag Archives: DRUGS

Breast Cancer Drugs in Late-Stage Development/Recently Approved

  The article is 2012-2013 based and reader discretion is sought to ascertian the stage of approval Breast Cancer Drugs in Late-Stage Development/Recently Approved   Afinitor® (everolimus) http://newdrugapprovals.wordpress.com/2013/04/27/drug-spotlight-afinitor-everolimus-novartis/ Sponsor: Novartis Method of Action: Mammalian target of rapamycin (mTOR) inhibitor Indications/Phase of Trial: Hepatocellular carcinoma; … Continue reading

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Amide Hydrogenation in Flow Reactor

http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html Amide Hydrogenation in Flow Reactor (wiley) Amines are produced by amide hydrogenation over a bimetallic platinum–rhenium catalyst in a high-throughput vertical flow reactor Read more http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html Share this:

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Teaching Old Drugs New Tricks

A library of novel 5-nitroimidazole antibiotics displayed broad-spectrum activity Read more Share this:

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Green N-Methylation of Electron Deficient Pyrroles with Dimethylcarbonate

The N-methylation of electron-deficient pyrroles was affected using dimethyl carbonate in the presence of DMF and catalytic DABCO. This alkylation methodology has proven useful for the alkylation of a variety of pyrroles in 72−98% yields and is considered to be greenchemistry relative … Continue reading

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Article On Alternative Solvents:  Shades of Green

The use of alternative reaction solvents is reviewed in terms of life cycle. Supercritical CO2, ionic liquids, fluorous solvents, water, and renewable organics are compared on the basis of their solvency, ease of use, reusability, health and safety, environmental impact, and economic cost. … Continue reading

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RABEPRAZOLE

Pariprazole sodium;Rabeprazole sodium;LY-307640;E-3810;Aciphex;Pariet Rabeprazole /ˌræ.ˈbɛp.ræ.zɔːl/ is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as the sodium salt under the brand names AcipHex (/ˈæsɨfɛks/, referring to pH) in the US, Pariet in Europe, Brazil, Canada, Japan, Russia and Australia, Acigard, Cyra, … Continue reading

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MOLECULAR BIOTECHNOLOGY

Molecular Biotechnology from sangita Share this:

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Axial-to-central chirality transfer in cyclization processes

Axial-to-central chirality transfer in cyclization processes Substrates, bearing axial chirality, can cyclize intra- or inter-molecularly with concomitant transfer of axial-to-central chirality to produce at least one stereocenter. In order to satisfy a strict definition of axial-to-central chirality transfer, the initial … Continue reading

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An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature

An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature Green Chem., 2013, Advance Article DOI: 10.1039/C3GC41469H, Paper Guodong Ding, Weitao Wang, Tao Jiang, Buxing Han The Pd/bentonite catalyst prepared by a simple impregnation method in water is … Continue reading

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Seeding removes barrier to curious cocrystal

Once the heteronuclear seeds had been used in the lab, the cocrystal formed regardless of whether or not the seeds were used The caffeine•benzoic acid cocrystal that has eluded scientists for 60 years has finally been crystallised Cocrystals are crystalline … Continue reading

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