Tag: ORGANIC CHEMISTRY

ARTEMETHER, FIGHT AGAINST MALARIA Artemether (INN) is an antimalarial for the treatment of multi-drug resistant strains offalciparum malaria. It is combined with Lumefantrine and sold by Novartis under the brand names Riamet and Co-Artem. Bill together with Rodger Stringham and David Teager report on an improved process for the conversion of artemisinin to artemether in Organic Process Research & Development (DOI). step 1 was smooth… Continue reading ARTEMETHER, FIGHT AGAINST MALARIA

The Fráter-Seebach alkylation is the stereoselective alkylation of chiral beta-hydroxy esters using superbases such as LDA or LiHMDS. This organic reaction was first reported by G. Fráter in 1979 (DOI DOI). In the original Fráter publication the starting material is ethyl acetoacetate 1, stereoselectively converted to the beta-hydroxy ester 2 with Baker’s yeast, converted to the dianion 3 with LDA and finally alkylated with iodomethanein HMPA to 4.