ARTEMETHER, FIGHT AGAINST MALARIA Artemether (INN) is an antimalarial for the treatment of multi-drug resistant strains offalciparum malaria. It is combined with Lumefantrine and sold by Novartis under the brand names Riamet and Co-Artem. Bill together with Rodger Stringham and David Teager report on an improved process for the conversion of artemisinin to artemether in Organic Process Research & Development (DOI). step 1 was smooth… Continue reading ARTEMETHER, FIGHT AGAINST MALARIA
Tag: ORGANIC CHEMISTRY
The Fráter-Seebach alkylation
The Fráter-Seebach alkylation is the stereoselective alkylation of chiral beta-hydroxy esters using superbases such as LDA or LiHMDS. This organic reaction was first reported by G. Fráter in 1979 (DOI DOI). In the original Fráter publication the starting material is ethyl acetoacetate 1, stereoselectively converted to the beta-hydroxy ester 2 with Baker’s yeast, converted to the dianion 3 with LDA and finally alkylated with iodomethanein HMPA to 4. Share this:
MY SITE ON ORGANIC CHEMISTRY LITERATURE
https://sites.google.com/site/organicchemistryliterature/ IS THE LINK FOR ORGANIC CHEMISTRY SITE DR ANTHONY CRASTO Share this:
MILLION HITS ON GOOGLE
Congratulations! Your presentation titled “Anthony Crasto Glenmark scientist, helping millions with websites” has just crossed MILLION views. http://www.authorstream.com/Presentation/anthonycrasto1964-1247437-anthony-crasto-glenmark-scientist-helping-millions-with-websites/ THANKS AND REGARD’S *DR ANTHONY M CRASTO* amcrasto@gmail.com MOBILE-+91 9323115463 GLENMARK SCIENTIST , NAVIMUMBAI, INDIA web link https://sites.google.com/site/amcrasto/ https://sites.google.com/site/anthonycrastoorganicchemistry/sites—my-own-on-the-net Congratulations! Your presentation titled “Anthony Crasto Glenmark scientist, helping millions with websites” has just crossed MILLION views. アンソニー 安东尼 Энтони … Continue reading MILLION HITS ON GOOGLE