Deprecated: Return type of Endurance_Collection::offsetExists($key) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 418

Deprecated: Return type of Endurance_Collection::offsetGet($key) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 429

Deprecated: Return type of Endurance_Collection::offsetSet($key, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 439

Deprecated: Return type of Endurance_Collection::offsetUnset($key) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 452

Deprecated: Return type of Endurance_Collection::count() should either be compatible with Countable::count(): int, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 82

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The Fráter-Seebach alkylation – EUREKAMOMENTS IN ORGANIC CHEMISTRY

The Fráter-Seebach alkylation

The Fráter-Seebach alkylation is the stereoselective alkylation of chiral

beta-hydroxy esters using superbases such as LDA or LiHMDS.

This organic reaction was first reported by G. Fráter in 1979 (DOI DOI).

In the original Fráter publication the starting material is ethyl acetoacetate 1, stereoselectively converted to the beta-hydroxy ester 2 with Baker’s yeast, converted to the dianion 3 with LDA and finally alkylated with iodomethanein HMPA to 4.

By DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D,( ICT), Worlddrugtracker, Helping millions with chemistry sites, million hits on google

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