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catalysis – EUREKAMOMENTS IN ORGANIC CHEMISTRY https://amcrasto.theeurekamoments.com DR ANTHONY MELVIN CRASTO Ph.D, WorldDrugTracker, Glenmark scientist ( Ph.D, ICT) helping millions with chemistry websites, million hits on google sites, Intention is to help chemists across the world, content is academic Wed, 13 Nov 2013 04:41:14 +0000 en-US hourly 1 https://wordpress.org/?v=6.5.2 Amide Hydrogenation in Flow Reactor https://amcrasto.theeurekamoments.com/2013/11/13/amide-hydrogenation-in-flow-reactor/ Wed, 13 Nov 2013 04:41:14 +0000 http://amcrasto.theeurekamoments.com/?p=1194 thumbnail image: Amide Hydrogenation in Flow Reactor

http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html

Amide Hydrogenation in Flow Reactor (wiley)

Amines are produced by amide hydrogenation over a bimetallic platinum–rhenium catalyst in a high-throughput vertical flow reactor

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]]> An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature https://amcrasto.theeurekamoments.com/2013/10/08/an-efficient-palladium-catalyst-on-bentonite-for-suzuki-miyaura-reaction-at-room-temperature/ Tue, 08 Oct 2013 07:32:01 +0000 http://amcrasto.theeurekamoments.com/?p=1147 Continue reading An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature]]>

Green Chem., 2013, Advance Article
DOI: 10.1039/C3GC41469H, Paper
Guodong Ding, Weitao Wang, Tao Jiang, Buxing Han
The Pd/bentonite catalyst prepared by a simple impregnation method in water is very active and stable for the Suzuki-Miyaura reaction.
Clays, which are nontoxic, abundant, and cheap, are very promising supports for the design and preparation of green catalysts. In this work, the Pd/bentonite catalyst was fabricated by a simple impregnation method using water as the medium. The catalyst was characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), transmission electron spectroscopy (TEM), X-ray photoelectron (XPS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES) techniques. The performance of Pd/bentonite in the Suzuki–Miyaura reaction was studied. It was found that for aryl bromides and iodides with various electron-donating and electron-withdrawing groups such as –CH3, –OCH3, –Cl, –CN, –F, –COCH3 and –NO2, the coupling reaction of substrates with arylboronic acid proceeded smoothly at low catalyst loading (Pd 0.06 mol%) under ambient temperature. The catalyst could be reused at least 7 times without any decrease in activity.
]]> Cyclodextrin-Modified Zeolites as Drug-Delivery Nanocontainers https://amcrasto.theeurekamoments.com/2013/09/25/cyclodextrin-modified-zeolites-as-drug-delivery-nanocontainers/ Wed, 25 Sep 2013 07:18:36 +0000 http://amcrasto.theeurekamoments.com/?p=1128 Continue reading Cyclodextrin-Modified Zeolites as Drug-Delivery Nanocontainers]]>

Zeolites modified with aminoalkoxysilanes and cyclodextrin show different uptake and release properties depending on which silane is used

Multifunctional nanocontainers for imaging, targeting, and drug release are a main research area in bio-nanomedicine. Jurriaan Huskens and colleagues, University of Twente, The Netherlands, have functionalized nanoporous zeolite L crystals with β-cyclodextrin (CD) to give multifunctional systems that have the potential for encapsulation of drug molecules inside the zeolite pores and noncovalent attachment of other, for example, targeting, ligand molecules on its surface.

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http://www.chemistryviews.org/details/ezine/5242131/Cyclodextrin-Modified_Zeolites_as_Drug-Delivery_Nanocontainers.html

]]> Ternary modified TiO2 as a simple and efficient photocatalyst for green organic synthesis https://amcrasto.theeurekamoments.com/2013/08/05/ternary-modified-tio2-as-a-simple-and-efficient-photocatalyst-for-green-organic-synthesis/ Mon, 05 Aug 2013 03:41:10 +0000 http://amcrasto.theeurekamoments.com/?p=1063 Continue reading Ternary modified TiO2 as a simple and efficient photocatalyst for green organic synthesis]]> Graphical abstract: Ternary modified TiO2 as a simple and efficient photocatalyst for green organic synthesis 

TiO2 ternary-modified with Fe3+, Ni2+, and Au nanoparticles exhibited a noticeable photocatalytic activity for selective cyclohexane oxidation with O2 under sunlight irradiation.

Ternary modified TiO2 as a simple and efficient photocatalyst for green organic synthesis

 
*
Corresponding authors
a
World Premier International (WPI) Research Center, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
E-mail: IDE.Yusuke@nims.go.jp ;
Fax: +81-29-860-4826
b
Graduate School of Engineering, Department of Applied Chemistry, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Japan
Chem. Commun., 2013,49, 3652-3654

DOI: 10.1039/C3CC41174E
Received 13 Feb 2013, Accepted 15 Mar 2013
First published online 15 Mar 2013

 

]]> Cu(II)-catalyzed decarboxylative acylation of acyl C–H of formamides with -oxocarboxylic acids leading to -ketoamides https://amcrasto.theeurekamoments.com/2013/08/05/cuii-catalyzed-decarboxylative-acylation-of-acyl-c-h-of-formamides-with-oxocarboxylic-acids-leading-to-ketoamides/ Mon, 05 Aug 2013 03:37:17 +0000 http://amcrasto.theeurekamoments.com/?p=1056 Continue reading Cu(II)-catalyzed decarboxylative acylation of acyl C–H of formamides with -oxocarboxylic acids leading to -ketoamides]]>    Graphical abstract: Cu(ii)-catalyzed decarboxylative acylation of acyl C–H of formamides with α-oxocarboxylic acids leading to α-ketoamides 

Cu(II)-catalyzed decarboxylative acylation of acyl C–H of formamides with -oxocarboxylic acids leading to -ketoamides
Dengke Li,a   Min Wang,*a   Jie Liu,a   Qiong Zhaoa and   Lei Wang*ab  
Chem. Commun., 2013, 49(35), 3640-3642  
 http://pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc41188eDOI: 10.1039/C3CC41188E

 
 
 
CuBr2-catalyzed decarboxylative acylation of the acyl C–H of N-monosubstituted and N,N-disubstituted formamides with α-oxocarboxylic acids leading to α-ketoamides was developed, which generated the corresponding products in good yields.
 
 
 
Corresponding authors
a
Department of Chemistry, Huaibei Normal University, Huaibei, P. R. China
E-mail: leiwang@chnu.edu.cn ;
Fax: +86-561-309-0518 ;
Tel: +86-561-380-2069
b
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
]]> Physicists Discover Theoretical Possibility of Large, Hollow Magnetic Cage Molecules https://amcrasto.theeurekamoments.com/2013/08/02/physicists-discover-theoretical-possibility-of-large-hollow-magnetic-cage-molecules/ Fri, 02 Aug 2013 07:34:10 +0000 http://amcrasto.theeurekamoments.com/?p=1042 Continue reading Physicists Discover Theoretical Possibility of Large, Hollow Magnetic Cage Molecules]]>

Illustration depicts a Mn24C18 cluster carrying a magnetic moment of 70 Bohr magnetons. (Credit: Image courtesy of Menghao Wu, Ph.D./VCU.)
Virginia Commonwealth University researchers have discovered, in theory, the possibility of creating large, hollow magnetic cage molecules that could one day be used in medicine as a drug delivery system to non-invasively treat tumors, and in other emerging technologies
Virginia Commonwealth University (2013, July 31). Physicists discover theoretical possibility of large, hollow magnetic cage molecules. ScienceDaily. Retrieved August 2, 2013, from http://www.sciencedaily.com­ /releases/2013/07/130731122916.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fmatter_energy%2Forganic_chemistry+%28ScienceDaily%3A+Matter+%26+Energy+News+–+Organic+Chemistry%29
]]> Vitamin B12: chemical modifications https://amcrasto.theeurekamoments.com/2013/07/31/vitamin-b12-chemical-modifications/ Wed, 31 Jul 2013 07:45:11 +0000 http://amcrasto.theeurekamoments.com/?p=1033 Continue reading Vitamin B12: chemical modifications]]>

Chem. Soc. Rev., 2013, 42,6605-6619
DOI: 10.1039/C3CS60062A, Tutorial Review
Keith o Proinsias, Maciej Giedyk, Dorota Gryko
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland 
E-mail: dorota.gryko@icho.edu.pl
Lord Alexander B. Todd wrote: “Vitamin B12turned out to be a substance of frightening complexity“. This review focuses on the chemistry of this complex molecule and its derivatives giving the researcher an introduction to the field of this fascinating molecule.

Vitamin B12: chemical modifications

Vitamin B12 plays a key role in many metabolic processes occurring in all mammals. Over the years its biological role has been extensively studied generating a lot of interest in the chemistry of this vital molecule. This established a variety of new methodologies for the synthesis and analysis of new cobalamin derivatives as well as creative purification techniques. This tutorial review summarizes all the advancements made in this area, providing a deeper insight into vitamin B12 chemistry.

http://pubs.rsc.org/en/Content/ArticleLanding/2013/CS/C3CS60062A?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FCS+%28RSC+-+Chem.+Soc.+Rev.+latest+articles%29

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]]> Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications https://amcrasto.theeurekamoments.com/2013/07/31/conjugated-polymer-nanoparticles-preparation-properties-functionalization-and-biological-applications/ Wed, 31 Jul 2013 07:41:42 +0000 http://amcrasto.theeurekamoments.com/?p=1030 Continue reading Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications]]>

Chem. Soc. Rev., 2013, 42,6620-6633
DOI: 10.1039/C3CS60036J, Tutorial Review
Liheng Feng, Chunlei Zhu, Huanxiang Yuan, Libing Liu, Fengting Lv, Shu Wang
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China 
E-mail: wangshu@iccas.ac.cn
This review provides an overview of the latest advancement in preparation, properties, functionalization and biological applications of conjugated polymer nanoparticles.

Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications

In the past few years, conjugated polymer nanoparticles (CPNs) have been successfully prepared and applied in the biological field because of their unique opto-electronic properties. The rapid development of CPNs is mainly attributed to their simple synthesis procedures and easy separation steps. The advantages of CPNs include high brightness, excellent photostability, low cytotoxicity, high quantum yield and versatile surface modification. The functionalization of CPNs with specific recognition elements imparts them good ability for targeted recognition and imaging in vitro and in vivo. CPNs can be applied to deliver drug and gene, and simultaneously to real-time monitor the release process due to their self-luminous characteristics. Moreover, CPNs can sensitize oxygen molecules to generate reactive oxygen species (ROS) which can kill adjacent bacteria and tumor cells. In this tutorial review, we provide a recent development of the preparation methods, properties, and functionalization strategies of CPNs, especially discussing their biological applications in targeted imaging, drug/gene delivery and biomedicine. The challenges and outlooks in this field will also be discussed.

http://pubs.rsc.org/en/Content/ArticleLanding/2013/CS/C3CS60036J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FCS+%28RSC+-+Chem.+Soc.+Rev.+latest+articles%29

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]]> Highlights from ASMC’13 – Advances in Synthetic and Medicinal Chemistry – May 5-8 2013, Moscow, Russia https://amcrasto.theeurekamoments.com/2013/07/31/highlights-from-asmc13-advances-in-synthetic-and-medicinal-chemistry-may-5-8-2013-moscow-russia/ Wed, 31 Jul 2013 07:33:18 +0000 http://amcrasto.theeurekamoments.com/?p=1026 Continue reading Highlights from ASMC’13 – Advances in Synthetic and Medicinal Chemistry – May 5-8 2013, Moscow, Russia]]>

Med. Chem. Commun., 2013, 4,1138-1144
DOI: 10.1039/C3MD90017G, Conference Report
Edmond Differding
 
EFMC & Differding Consulting, Route de Blocry 55, 1348 Louvain-la-Neuve, Belgium 
E-mail: edmond@differding.com
Received 14 Jun 2013, Accepted 14 Jun 2013
First published online 18 Jul 2013
ASMC’13 Moscow focused on new synthetic methodologies and aimed at expanding the drug discovery space from small to large molecules, including carbohydrates, novel protein scaffolds, dendrimers, and genes (Picture: St Basil’s Cathedral in Moscow’s Red Square)

Highlights from ASMC’13 – Advances in Synthetic and Medicinal Chemistry – May 5-8 2013, Moscow, Russia

ASMC’13 Moscow (May 5–8, 2013) focused on new synthetic methodologies and aimed at expanding the drug discovery space from small to large molecules, including carbohydrates, novel protein scaffolds, dendrimers, and genes

 

 

]]> 240 boron atoms in a single molecular species https://amcrasto.theeurekamoments.com/2013/07/30/240-boron-atoms-in-a-single-molecular-species/ Tue, 30 Jul 2013 01:30:22 +0000 http://amcrasto.theeurekamoments.com/?p=1023 Continue reading 240 boron atoms in a single molecular species]]> The cuboctahedron consists of copper paddle-wheel nodes and carborane–isophthalic acids

Scientists in the US have made a molecular species containing the highest number of boron atoms ever recorded in a crystallographically characterised molecular species. The unique supramolecular cuboctahedron contains 240 boron atoms and was synthesised by Chad Mirkin and colleagues at Northwestern University in Evanston, Illinois, via coordination-driven assembly.

read all at

http://www.rsc.org/chemistryworld/2013/07/nanostructure-highest-number-boron-atoms

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