Vitamin B12: chemical modifications

Chem. Soc. Rev., 2013, 42,6605-6619
DOI: 10.1039/C3CS60062A, Tutorial Review

Keith o Proinsias, Maciej Giedyk, Dorota Gryko

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland 
E-mail: dorota.gryko@icho.edu.pl
Lord Alexander B. Todd wrote: “Vitamin B₁₂turned out to be a substance of frightening complexity“. This review focuses on the chemistry of this complex molecule and its derivatives giving the researcher an introduction to the field of this fascinating molecule.

Vitamin B12: chemical modifications

Vitamin B₁₂ plays a key role in many metabolic processes occurring in all mammals. Over the years its biological role has been extensively studied generating a lot of interest in the chemistry of this vital molecule. This established a variety of new methodologies for the synthesis and analysis of new cobalamin derivatives as well as creative purification techniques. This tutorial review summarizes all the advancements made in this area, providing a deeper insight into vitamin B₁₂ chemistry.

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