Deprecated: Return type of Endurance_Collection::offsetExists($key) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 418

Deprecated: Return type of Endurance_Collection::offsetGet($key) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 429

Deprecated: Return type of Endurance_Collection::offsetSet($key, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 439

Deprecated: Return type of Endurance_Collection::offsetUnset($key) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 452

Deprecated: Return type of Endurance_Collection::count() should either be compatible with Countable::count(): int, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 82

Deprecated: Return type of Endurance_Collection::getIterator() should either be compatible with IteratorAggregate::getIterator(): Traversable, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home4/theeurek/public_html/amcrasto/wp-content/plugins/bluehost-wordpress-plugin/vendor/bluehost/endurance-wp-module-loader/includes/Collection.php on line 219
IMATINIB SYNTHESIS – EUREKAMOMENTS IN ORGANIC CHEMISTRY

IMATINIB SYNTHESIS

As an example of research aimed at industrial production one involving imatinib. This cancer drug was one of the first offspring of rational drug design . A group of Northwest University researchers set out to improve the existing Novartis procedure DOI and here is how they did it.

2-acetylpyridine (1) was alkylated with the acetal of N,N-dimethylformamide 2 to enamine 3. A pyrimidine ring in 5was formed with base and reagent guanidine nitrate 4 and nitrotoluene fragment 6 was added in a Ullmann-type reaction with CuI generating secondary amine 7. The nitro group was reduced by hydrazine / FeCl₃/C to the amine which was then converted to amide 8 with acid chloride 9. The final step is addition of piperazine 10 to form imatinib11.

By DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D,( ICT), Worlddrugtracker, Helping millions with chemistry sites, million hits on google

View all of DR ANTHONY MELVIN CRASTO Ph.D's posts.