Monthly Archives: November 2012

Substituted indole derivatives for the treatment of immunological disorders,WO 2012156936, Novartis AG, Protein kinase C theta inhibitor

TITLE-Substituted indole derivatives for the treatment of immunological disorders Protein kinase C theta inhibitor WO 2012156936, 22.11.2012, Novartis AG GENERAL STRUCTURE DESCRIBED IS Phosphoric acid mono-[3-[3-(4,7-diaza-spiro[2.5]oct-7-yl)-isoquinolin-1 -yl]-4-(7-methyl-1 H-indol-3-yl)-2,5-dioxo-2,5-dihydro-pyrrol-1 -ylmethyl] ester 1H-NMR (400 MHz, DMSO-d6): 12.10 (s, 1 H), 8.08 (d, 1 … Continue reading

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cis z jasmone

Jasmone is a natural organic compound extracted from the volatile portion of the oil fromjasmine flowers. It is a colorless to pale yellow liquid that has the odor of jasmine. Jasmone can exist in two isomeric forms with differing geometry around the pentenyl double bond, cis-jasmone … Continue reading

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WO 2012130821, BENZOIC ACID SALT OF OTAMIXABAN (SANOFI)

Otamixaban (INN) is a direct factor Xa inhibitor,[1] currently being developed by the French pharmaceutical company Sanofi-Aventis as a treatment for acute coronary syndrome. Methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate Guertin KR, Choi YM (2007). “The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development”. Curr. Med. Chem. 14 (23): … Continue reading

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Sucampo and Abbott Announce Launch of AMITIZA in Japan, 26 nov 2012

Sucampo and Abbott Announce Launch of AMITIZA in Japan Product is Japan’s Only Prescription Medicine for Chronic Constipation Lubiprostone CAS number 136790-76-6  Sucampo Pharmaceuticals, Inc. and Abbott today announced the availability of AMITIZA® (lubiprostone) in Japan, a prescription medicine for the treatment of … Continue reading

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Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012

Total synthesis of artemisinin, WO2012154906  (A1) 15th nov 2012 link at espacenet   http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20121115&CC=WO&NR=2012154906A1&KC=A1 Indiana University Research And Technology Corporation Inventors Cook, Silas; Zhu, Chun-Yin Application number: WO2012US37214 2012 05 10 Priority number(s): US201161484317P 2011 05 10 Oxidative synthesis; Rearrangement synthesis, … Continue reading

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Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide)

Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide) Sanofi announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending the approval … Continue reading

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A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-­Dioxolanes under Basic Conditions

A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-­Dioxolanes under Basic Conditions Hassner, Alfred; et al Department of Chemistry,Bar-IlanUniversity,Ramat-Gan52900,Israel Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N-hydroxybenzenesulfonamide, its O-benzyl derivative, … Continue reading

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IONIC LIQUIDS, USES

  Ionic liquids are very popular materials and they enjoy a plethora of applications in various domains of physical sciences. For example, they are used as “solvents” for organic, organometallic syntheses and catalysis, as electrolytes in electrochemistry, in fuel and … Continue reading

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Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent

Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent Saeed Khodabakhshi Department of Chemistry, Islamic Azad University, Gachsaran Branch, Gachsaran, Iran, Organic Chemistry International Volume 2012 (2012), Article ID 306162, 5 pages doi:10.1155/2012/306162 http://www.hindawi.com/journals/oci/2012/306162/ General Procedure for … Continue reading

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A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS

https://docs.google.com/viewer?url=http%3A%2F%2Fwww.mjcce.org.mk%2FPDF%2F28_2_425.pdf A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS Arpita Dugar, Anil Kumar, Rameshwar Ameta, Suresh C. AmetaMACEDONIAN JOURNAL OF CHEM AND CHEM ENG, 2009, V28,2, PG 163 Photochemical aromatic nitration of phenol and salicylic acid has been carried … Continue reading

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