TITLE-Substituted indole derivatives for the treatment of immunological disorders Protein kinase C theta inhibitor WO 2012156936, 22.11.2012, Novartis AG GENERAL STRUCTURE DESCRIBED IS Phosphoric acid mono-[3-[3-(4,7-diaza-spiro[2.5]oct-7-yl)-isoquinolin-1 -yl]-4-(7-methyl-1 H-indol-3-yl)-2,5-dioxo-2,5-dihydro-pyrrol-1 -ylmethyl] ester 1H-NMR (400 MHz, DMSO-d6): 12.10 (s, 1 H), 8.08 (d, 1 H), 7.65-7.61 (m, 2H), 7.44 (f, 1 H), 7.20 (s, 1 H), 7.06 (f, 1… Continue reading Substituted indole derivatives for the treatment of immunological disorders,WO 2012156936, Novartis AG, Protein kinase C theta inhibitor
Month: November 2012
cis z jasmone
Jasmone is a natural organic compound extracted from the volatile portion of the oil fromjasmine flowers. It is a colorless to pale yellow liquid that has the odor of jasmine. Jasmone can exist in two isomeric forms with differing geometry around the pentenyl double bond, cis-jasmone and trans-jasmone. The natural extract contains only the cis form, while synthetic material is often… Continue reading cis z jasmone
WO 2012130821, BENZOIC ACID SALT OF OTAMIXABAN (SANOFI)
Otamixaban (INN) is a direct factor Xa inhibitor,[1] currently being developed by the French pharmaceutical company Sanofi-Aventis as a treatment for acute coronary syndrome. Methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate Guertin KR, Choi YM (2007). “The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development”. Curr. Med. Chem. 14 (23): 2471–81.doi:10.2174/092986707782023659. PMID 17979700. Methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1 -oxidopyridin-4-yl)benzoyl]amino}butanoate, (CAS number 193153-04-7) has the International Nonproprietary Name Otamixaban The present… Continue reading WO 2012130821, BENZOIC ACID SALT OF OTAMIXABAN (SANOFI)
Sucampo and Abbott Announce Launch of AMITIZA in Japan, 26 nov 2012
Sucampo and Abbott Announce Launch of AMITIZA in Japan Product is Japan’s Only Prescription Medicine for Chronic Constipation Lubiprostone CAS number 136790-76-6 Sucampo Pharmaceuticals, Inc. and Abbott today announced the availability of AMITIZA® (lubiprostone) in Japan, a prescription medicine for the treatment of chronic constipation not caused by organic diseases. AMITIZA was approved by the Ministry of Health,… Continue reading Sucampo and Abbott Announce Launch of AMITIZA in Japan, 26 nov 2012
Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012
Total synthesis of artemisinin, WO2012154906 (A1) 15th nov 2012 link at espacenet http://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20121115&CC=WO&NR=2012154906A1&KC=A1 Indiana University Research And Technology Corporation Inventors Cook, Silas; Zhu, Chun-Yin Application number: WO2012US37214 2012 05 10 Priority number(s): US201161484317P 2011 05 10 Oxidative synthesis; Rearrangement synthesis, The present invention provides a method for manufacturing artemisinin and its congeners from cyclohexenone as… Continue reading Total synthesis of artemisinin, WO 2012154906 (A1) 15th nov 2012
Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide)
Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide) Sanofi announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending the approval of once-daily Lyxumia® (lixisenatide) for the treatment of adults with type 2 diabetes mellitus to… Continue reading Sanofi Receives Positive CHMP Opinion in the European Union for Once-Daily Lyxumia® (lixisenatide)
A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions
A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions Hassner, Alfred; et al Department of Chemistry,Bar-IlanUniversity,Ramat-Gan52900,Israel Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N-hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence… Continue reading A Mild, Room-Temperature Protection of Ketones and Aldehydes as 1,3-Dioxolanes under Basic Conditions
IONIC LIQUIDS, USES
Ionic liquids are very popular materials and they enjoy a plethora of applications in various domains of physical sciences. For example, they are used as “solvents” for organic, organometallic syntheses and catalysis, as electrolytes in electrochemistry, in fuel and solar cells, as lubricants, as a stationary phase for chromatography, as matrices for mass spectrometry,… Continue reading IONIC LIQUIDS, USES
Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent
Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent Saeed Khodabakhshi Department of Chemistry, Islamic Azad University, Gachsaran Branch, Gachsaran, Iran, Organic Chemistry International Volume 2012 (2012), Article ID 306162, 5 pages doi:10.1155/2012/306162 http://www.hindawi.com/journals/oci/2012/306162/ General Procedure for the Preparation of Coumarin 3 A mixture of phenol 1 (1 mmol), β-ketoesters 2 (1 mmol), and… Continue reading Barium Dichloride as a Powerful and Inexpensive Catalyst for the Pechmann Condensation without Using Solvent
A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS
https://docs.google.com/viewer?url=http%3A%2F%2Fwww.mjcce.org.mk%2FPDF%2F28_2_425.pdf A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS Arpita Dugar, Anil Kumar, Rameshwar Ameta, Suresh C. AmetaMACEDONIAN JOURNAL OF CHEM AND CHEM ENG, 2009, V28,2, PG 163 Photochemical aromatic nitration of phenol and salicylic acid has been carried out in the presence of UV radiations and formation of products has been observed spectrophotometrically.… Continue reading A GREEN CHEMICAL APPROACH FOR NITRATION OF AROMATIC COMPOUNDS