![\"\"](\"https:\/\/en.wikipedia.org\/wiki\/File:Ubiquinone.png\")
<\/a><\/td>\n<\/tr>\n2-[(2E<\/i>,6E<\/i>,10E<\/i>,14E<\/i>,18E<\/i>,22E<\/i>,26E<\/i>,30E<\/i>,34E<\/i>)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5, 6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione<\/p>\n<\/div>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Coenzyme Q10<\/sub>\u00a0(ubiquinone-10, CoQ10<\/sub>, CoQ, Q10<\/sub>\u00a0or simply Q) is aubiquinone\u00a0containing 10 isoprenoid units. First discovered in 1957 by Crane\u00a0et al.<\/i>\u00a0[1], its chemical structure was determined by\u00a0Karl Folkers\u00a0[2], who later won the\u00a0Priestley medal\u00a0from the American Chemical Society. This oil-soluble, vitamin-like micronutrient forms part of the electron transport chain which, in the process of aerobic respiration, generates 95% of the human body’s energy asATP\u00a0[3].<\/p>\n CoQ<\/b>, or\u00a0Q10<\/sub><\/b>\u00a0is a\u00a01,4-benzoquinone, where\u00a0Q<\/b>\u00a0refers to the\u00a0quinone\u00a0chemical group, and\u00a010<\/b>\u00a0refers to the number of\u00a0isoprenylchemical subunits in its tail.<\/p>\n This oil-soluble, vitamin-like substance is present in most\u00a0eukaryotic\u00a0cells, primarily in themitochondria. It is a component of the\u00a0electron transport chain\u00a0and participates in\u00a0aerobic cellular respiration, generating energy in the form of\u00a0ATP. Ninety-five percent of the human body\u2019s energy is generated this way.\u00a0Therefore, those organs with the highest energy requirements\u2014such as the heart, liver and kidney\u2014have the highest CoQ10<\/sub>concentrations.\u00a0There are three\u00a0redox\u00a0states of CoQ10<\/sub>: fully oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol). The capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it to perform its functions in the electron transport chain and as an antioxidant respectively.<\/p>\n Coenzyme Q10<\/sub>\u00a0is synthesized\u00a0de novo<\/i>\u00a0by every cell in the body, but levels decrease with age, in several clinical disorders, and in patients administered certain drugs such as\u00a0hydroxymethylglutaryl-CoA reductase inhibitors\u00a0(commonly known as\u00a0statins). With cardiovascular disease being a leading cause of death in the West, evidence that oral supplements of coenzyme Q10<\/sub>\u00a0can benefit patients suffering from heart disease is of increasing appeal. Evidence is also accumulating for its effective treatment of other ailments including mitochondrial disorders and neurodegenerative diseases such as\u00a0amyotrophic lateral sclerosis\u00a0(ALS),\u00a0Huntington’s disease\u00a0and\u00a0Parkinson’s disease.<\/p>\n Coenzyme Q10<\/sub>\u00a0is one of the best-selling dietary supplements worldwide, available over the counter from health food shops and pharmacies. Its popularity may be due to the wide-ranging claims made for its effectiveness in a myriad of human health issues: it is marketed as an energy booster; a periodontal health promoter; an agent for maintaining normal blood-cholesterol levels; an enhancer of cognitive function; a remedy for hypertension, migraine headaches, radiation injury and cancer; and a superdrug capable of delaying or even reversing the effects of aging. However, perusal of the scientific literature reveals that, while data supporting some claims are forthcoming (such as in the case of heart disease and mitochondrial function), coenzyme Q10<\/sub>\u00a0is neither panacea nor elixir [4,5].<\/p>\n Coenzyme Q10 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5, 6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione Coenzyme Q10\u00a0(ubiquinone-10, CoQ10, CoQ, Q10\u00a0or simply Q) is aubiquinone\u00a0containing 10 isoprenoid units. First discovered in 1957 by Crane\u00a0et al.\u00a0[1], its chemical structure was determined by\u00a0Karl Folkers\u00a0[2], who later won the\u00a0Priestley medal\u00a0from the American Chemical Society. This oil-soluble, vitamin-like micronutrient forms part of the electron transport chain which, in the process of… Continue reading Coenzyme Q10<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33,28,19,3,1,37],"tags":[18,56,57,146,11,12,143,9,144,55],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/959"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=959"}],"version-history":[{"count":3,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/959\/revisions"}],"predecessor-version":[{"id":962,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/959\/revisions\/962"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}References<\/h3>\n
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