Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes<\/p>\n

\u5f88\u9ad8\u5174\u770b\u5230\u6765\u81ea\u4e2d\u56fd\u7684\u7cbe\u5f69\u6587\u7ae0<\/p>\n

http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jccs.201100474\/abstract<\/a><\/p>\n

DOI: 10.1002\/jccs.201100474<\/p>\n

Chiral 8-substituted 2-(8,10,10-trimethyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl)-phenols were prepared from a high enantiopurity (>97% ee) of (1R)-(+)-alpha-pinene, and assessed in the enantioselective addition of diethylzinc to substituted benzaldehydes, giving the (S)-alcohols with enantiomeric excess ranging from 33% to 89%. Interestingly, in all cases, except for those of ortho-chlorobenzaldehyde, ortho- and para-methoxybenzaldehydes, the ee was >71%.<\/p>\n

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Journal of the Chinese Chemical Society<\/h2>\n

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Volume 59, Issue 6, <\/a>pages 768\u2013781, June 2012<\/p>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes \u5f88\u9ad8\u5174\u770b\u5230\u6765\u81ea\u4e2d\u56fd\u7684\u7cbe\u5f69\u6587\u7ae0 http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jccs.201100474\/abstract DOI: 10.1002\/jccs.201100474 Chiral 8-substituted 2-(8,10,10-trimethyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl)-phenols were prepared from a high enantiopurity (>97% ee) of (1R)-(+)-alpha-pinene, and assessed in the enantioselective addition of diethylzinc to substituted benzaldehydes, giving the (S)-alcohols with enantiomeric excess ranging from 33% to 89%. Interestingly, in all cases,… Continue reading Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,4],"tags":[143,144],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/81"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=81"}],"version-history":[{"count":2,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/81\/revisions"}],"predecessor-version":[{"id":83,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/81\/revisions\/83"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=81"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=81"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=81"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}