<\/p>\n

<\/p>\n

Sirolimus<\/strong>\u00a0(INN<\/a>\/USAN<\/a>), also known as\u00a0rapamycin<\/strong>, is an\u00a0immunosuppressant<\/a>\u00a0drug used to prevent\u00a0rejection<\/a>\u00a0in\u00a0organ transplantation<\/a>; it is especially useful in\u00a0kidney<\/a>transplants. It prevents activation of\u00a0T cells<\/a>\u00a0and\u00a0B cells<\/a>\u00a0by inhibiting their response tointerleukin-2<\/a>\u00a0(IL-2).<\/p>\n

A\u00a0macrolide<\/a>, sirolimus was discovered by Brazilian researchers as a product of the bacterium\u00a0Streptomyces hygroscopicus<\/a><\/em>\u00a0in a soil sample from\u00a0Easter Island<\/a>[1]<\/a><\/sup>\u00a0\u2014 an island also known as Rapa Nui.[2]<\/a><\/sup>\u00a0It was approved by the FDA in September 1999 and is marketed under the trade name\u00a0Rapamune<\/strong>\u00a0by\u00a0Pfizer<\/a>\u00a0(formerly by\u00a0Wyeth<\/a>).<\/p>\n

Sirolimus was originally developed as an\u00a0antifungal<\/a>\u00a0agent. However, this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties. It has since been shown to prolong the life of mice and might also be useful in the treatment of certain\u00a0cancers<\/a>.<\/p>\n

<\/p>\n

V\u00e9zina C, Kudelski A, Sehgal SN (October 1975). “Rapamycin (AY-22,989), a new antifungal antibiotic”.\u00a0J. Antibiot.<\/em>\u00a028<\/strong>\u00a0(10): 721\\u20136.\u00a0PMID<\/a>\u00a01102508<\/a>.<\/p>\n

 <\/p>\n

According to Deepak Adhikari and colleagues, University of Gothenburg, Sweden, a solution to this problem consists of the immunosuppressant drug rapamycin\u00a0(pictured). The researchers demonstrated that this compound, a lipophilic macrolide inactivating mTORC1, inhibits the exhaustion of the pool of primordial follicles occurring in mice upon phosphatidylinositide 3-kinase hyper-activation. Thus, rapamycin may be used in the clinic to protect female fertility from the detrimental effects of ovotoxic agents such as chemotherapeutic drugs.<\/p>\n

The female reproductive lifespan<\/strong>\u00a0is determined by the pool of primordial follicles, ovarian structures containing immature eggs (oocytes) which periodically mature into cells which can be fertilized. While primordial follicles are gradually and physiologically lost with age, pathological conditions or exposure to environmental chemicals can accelerate their exhaustion leading to infertility.<\/p>\n

Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling<\/a>,
\nD. Adhikari, S. Risal, K. Liu, Y. Shen,
\nPLoS ONE<\/em>\u00a02013<\/strong>,\u00a08(1)<\/em>: e53810.
\nDOI: 10.1371\/journal.pone.0053810<\/a><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Sirolimus\u00a0(INN\/USAN), also known as\u00a0rapamycin, is an\u00a0immunosuppressant\u00a0drug used to prevent\u00a0rejection\u00a0in\u00a0organ transplantation; it is especially useful in\u00a0kidneytransplants. It prevents activation of\u00a0T cells\u00a0and\u00a0B cells\u00a0by inhibiting their response tointerleukin-2\u00a0(IL-2). A\u00a0macrolide, sirolimus was discovered by Brazilian researchers as a product of the bacterium\u00a0Streptomyces hygroscopicus\u00a0in a soil sample from\u00a0Easter Island[1]\u00a0\u2014 an island also known as Rapa Nui.[2]\u00a0It was approved by the… Continue reading Immunosuppressant Drug Rapamycin Helps Preserving Female Fertility<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,1],"tags":[146,143,144],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/568"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=568"}],"version-history":[{"count":6,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/568\/revisions"}],"predecessor-version":[{"id":574,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/568\/revisions\/574"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}