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{"id":531,"date":"2013-01-27T03:24:30","date_gmt":"2013-01-27T03:24:30","guid":{"rendered":"http:\/\/amcrasto.theeurekamoments.com\/?p=531"},"modified":"2013-01-27T03:25:22","modified_gmt":"2013-01-27T03:25:22","slug":"z-5-tetradecen-1-ol-potential-female-sex-attractant","status":"publish","type":"post","link":"https:\/\/amcrasto.theeurekamoments.com\/2013\/01\/27\/z-5-tetradecen-1-ol-potential-female-sex-attractant\/","title":{"rendered":"(Z)-5-tetradecen-1-ol, Potential female sex attractant"},"content":{"rendered":"

Follow my blog with Bloglovin<\/a> $\"(Z)-5-Tetradecen-1-ol\"$ <\/p>\n

(Z)-5-Tetradecen-1-ol, mw\u00a0 212.37,\u00a0\u00a0 formula\u00a0 C14H20O\u00a0\u00a0 CAS\u00a0\u00a0 40642-42-0<\/p>\n

Odorant receptors, present on nasal sensory neurons<\/strong>, perceive volatile compounds and regulate animal behavior such as reproduction. The nature of the ligands interacting with these receptors is, however, largely unknown.
\nKeiichi Yoshikawa and colleagues, University of Tokyo, Japan, shed new light on this issue. The researchers demonstrated that, in mice, preputial gland cells generate and secrete into the urine the unsaturated aliphatic alcohol (Z<\/em>)-5-tetradecen-1-ol (pictured). This compound is regulated by the male hormone testosterone and acts as a natural agonist of the mouse odorant receptor Olfr288, affecting attractiveness to female mice. The urine of males lacking (Z<\/em>)-5-tetradecen-1-ol, in fact, failed to attract females.<\/p>\n

$\"(9Z)-9-Tetradecene-14-ol$ <\/p>\n

By identifying a novel receptor-ligand interaction in the mouse olfactory system, this study offers new insights into the complex chemistry regulating reproductive behavior.<\/p>\n

An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor<\/a>,
\nK. Yoshikawa, H. Nakagawa, N. Mori, H. Watanabe, K. Touhara,
\nNature Chem. Biol<\/em>. 2013<\/strong>.
\nDOI: 10.1038\/nchembio.1164<\/a><\/li>\n
Ohloff, G. et al. 1977. Helv. Chim. Acta. 60:1161-1174.<\/li>\n
http:\/\/www.cas-msds.com\/40642-42-0<\/a><\/li>\n
\n\n\n\n\n\n\n\n\n
Bestmann, H.J., Brosche, T., Koschatzky, K.H., Michaelis, K., Platz, H., Vostrowsky, O., and Knauf, W. 1980. Pheromone XXX. Identifizierung eines neuartigen pheromonkomplexes aus der graseule Scotia exclamationis. Tetrahedron Lett. 21:747-750.<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
Kelkar, S.V., Reddy, G.B., and Kulkarni, G.H. 1989. Indian J. Chem. Sect. B. 28:980-981.<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
Ohloff, G., Vial, C., N\u00e4f, F., and Pawlak, M. 1977. Stereoselective syntheses of the isomeric 5, 10-pentadecadienals. Helv. Chim. Acta. 60:1161-1174.<\/td>\n<\/tr>\n
\u00a0 $\"(9Z)-9-Tetradecene-14-ol$ <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
Follow my blog with Bloglovin (Z)-5-Tetradecen-1-ol, mw\u00a0 212.37,\u00a0\u00a0 formula\u00a0 C14H20O\u00a0\u00a0 CAS\u00a0\u00a0 40642-42-0 Odorant receptors, present on nasal sensory neurons, perceive volatile compounds and regulate animal behavior such as reproduction. The nature of the ligands interacting with these receptors is, however, largely unknown. Keiichi Yoshikawa and colleagues, University of Tokyo, Japan, shed new light on this… Continue reading (Z)-5-tetradecen-1-ol, Potential female sex attractant<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,4],"tags":[143,10,144],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/531"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=531"}],"version-history":[{"count":8,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/531\/revisions"}],"predecessor-version":[{"id":541,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/531\/revisions\/541"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}