Features<\/strong>: single solvent system toluene\/water.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/center><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"
CETRIZINE BY Reiter, Trinka, Bartha ,Pongo, Volk, Simig\u00a0DOI Synthetic scale: 50 – 150 Kg Step 1: 4-chlorobenzophenoneorganic reduction\u00a0(sodium borohydride),\u00a0methyltrioctylammonium chloride\u00a0phase-transfer catalyst(toluene\/water) Step 2:\u00a0thionyl chloride\u00a0chlorination(toluene) Step 3: N-(2-hydroxyethyl)piperazineamine alkylation\u00a0(toluene) Step 4: free amine liberation\u00a0NaOHwater\/ toluene Step 5: 2-chloro-N,Ndimethylacetamide\u00a0O-alkylation(toluene), HCl workup Step 6:\u00a0Amide hydrolysis, NaOH \/ water Features: single solvent system toluene\/water.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,4],"tags":[143,144],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/51"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=51"}],"version-history":[{"count":1,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/51\/revisions"}],"predecessor-version":[{"id":52,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/51\/revisions\/52"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=51"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=51"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=51"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}