<\/p>\n

The \u03b1-tocopherol form of vitamin E<\/p>\n

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Vitamin E<\/strong>\u00a0refers to a group of eight fat-soluble compounds that include both\u00a0tocopherolsand\u00a0tocotrienols.^{[1]<\/sup>\u00a0There are many different forms of vitamin E, of which\u00a0\u03b3-tocopherol\u00a0is the most common in the North American diet.[2]<\/sup>\u00a0\u03b3-Tocopherol can be found in corn oil, soybean oil, margarine and dressings.[3]<\/sup>[4]<\/sup>\u00a0In the North American diet,\u00a0\u03b1-Tocopherol, the most biologically active form of vitamin E, is the second most common form of vitamin E. This variant of vitamin E can be found most abundantly in wheat germ oil, sunflower, and safflower oils.[4]<\/sup>[5]<\/sup>\u00a0It is a fat-soluble\u00a0antioxidant<\/a>\u00a0that stops the production of\u00a0reactive oxygen species\u00a0formed when fat undergoes oxidation.[6]<\/sup>[7]<\/sup>[8]<\/sup><\/p>\n}

<\/p>\n

\n
• Synthesis of Vitamin E<\/li>\n<\/ul>\n

  Vitamin E (CAS NO.:\u00a059-02-9), with other names as 2(R),5,7,8-Tetramethyl-2-[4(R),8(R),12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol, could be produced through the following synthetic routes.<\/a>,<\/p>\n

  \u00a0<\/div>\n

  \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/div>\n

  The chlorination of myrcene (I) with Cl_{2<\/sub>\u00a0in refluxing pentane gives the choromyrcene (II), and the hydrochlorination of (I) catalyzed by CuCl yields a mixture of geranyl\/neryl chloride (III). The reductive coupling of (II) and (III) by means of Mg and CuCl affords beta-springene (IV), which is condensed with 2,3,6-trimethylhydroquinone (V) by means of cyclooctadienyl rhodium chloride dimer [RhCl(COD)]2<\/sub>\u00a0and K2<\/sub>CO3<\/sub>\u00a0in refluxing toluene to provide the adduct (VI). The cyclization of (VI) by means of MeAlCl2<\/sub>\u00a0of Ts-OH in refluxing hexane furnishes the tocotrienol (VII), which is finally hydrogenated with H2<\/sub>\u00a0over Pd\/C in ethanol to give the target (rac)-vitamin E.<\/div>\n}

  <\/div>\n

  <\/div>\n

  <\/h2>\n

  <\/h2>\n

  \u00a0References<\/h2>\n

  \n
  1. Brigelius-Flohe, B; Traber (1999). “Vitamin E: function and metabolism”.\u00a0FASEB<\/em>\u00a013<\/strong>: 1145\u20131155.<\/li>\n
  2. Traber, MG (1998).\u00a0“The biological activity of vitamin E”<\/a>. The Linus Pauling Institute. Retrieved 6 March 2011.<\/li>\n
  3. Bieri, JG; Evarts (1974). “\u03b3-Tocopherol: metabolism, biological activity and significance in human vitamin E nutrition”.\u00a0American Journal of Clinical Nutrition<\/em>\u00a027<\/strong>\u00a0(9): 980\u2013986.\u00a0PMID<\/a>\u00a04472121<\/a>.<\/li>\n
  4. Brigelius-Floh\u00e9 R, Traber MG (1 July 1999). “Vitamin E: function and metabolism”.\u00a0FASEB J.<\/em>\u00a013<\/strong>\u00a0(10): 1145\u201355.\u00a0PMID<\/a>\u00a010385606<\/a>.<\/li>\n
  5. Reboul E, Richelle M, Perrot E, Desmoulins-Malezet C, Pirisi V, Borel P (15 November 2006). “Bioaccessibility of carotenoids and vitamin E from their main dietary sources”.\u00a0Journal of Agricultural and Food Chemistry<\/em>\u00a054<\/strong>\u00a0(23): 8749\u20138755.\u00a0doi<\/a>:10.1021\/jf061818s<\/a>.PMID<\/a>\u00a017090117<\/a>.<\/li>\n
  6. National Institute of Health (4 May 2009).\u00a0“Vitamin E fact sheet”<\/a>.<\/li>\n
  7. Herrera; Barbas, C (2001). “Vitamin E: action, metabolism and perspectives”.\u00a0Journal of Physiology and Biochemistry<\/em>\u00a057<\/strong>\u00a0(2): 43\u201356.doi<\/a>:10.1007\/BF03179812<\/a>.\u00a0PMID<\/a>\u00a011579997<\/a>.<\/li>\n
  8. Packer L, Weber SU, Rimbach G (2001).\u00a0“Molecular aspects of \u03b1-tocotrienol antioxidant action and cell signalling”<\/a>.\u00a0Journal of Nutrition<\/em>\u00a0131<\/strong>\u00a0(2): 369S\u201373S.\u00a0PMID<\/a>\u00a011160563<\/a>.<\/li>\n<\/ol>\n
     \n
     • Vitamin E bound to proteins<\/a>\u00a0in the\u00a0PDB<\/a><\/li>\n
     • Vitamin E<\/a>\u00a0Medline Plus, Medical Encyclopedia, U.S. National Library of Medicine<\/li>\n
     • Vitamin E<\/a>\u00a0Office of Dietary Supplements, National Institutes of Health<\/li>\n
     • Jane Higdon, “Vitamin E<\/a>“, Micronutrient Information Center,\u00a0Linus Pauling Institute<\/a>,\u00a0Oregon State University<\/a><\/em><\/li>\n
     • Vitamin E Food Charts<\/a><\/li>\n<\/ul>\n

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       <\/p>\n

       <\/p>\n

       <\/div>\n

        <\/p>\n","protected":false},"excerpt":{"rendered":"

       The \u03b1-tocopherol form of vitamin E Vitamin E\u00a0refers to a group of eight fat-soluble compounds that include both\u00a0tocopherolsand\u00a0tocotrienols.[1]\u00a0There are many different forms of vitamin E, of which\u00a0\u03b3-tocopherol\u00a0is the most common in the North American diet.[2]\u00a0\u03b3-Tocopherol can be found in corn oil, soybean oil, margarine and dressings.[3][4]\u00a0In the North American diet,\u00a0\u03b1-Tocopherol, the most biologically active form… Continue reading Synthesis of vitamin E<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[143],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/378"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=378"}],"version-history":[{"count":12,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/378\/revisions"}],"predecessor-version":[{"id":467,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/378\/revisions\/467"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}