Green Chem.<\/b><\/i>, 2017, Advance Article
\nDOI<\/b>: 10.1039\/C6GC03324E, Communication<\/div>\n
Shrikant G. Pharande, Alma Rosa Corrales Escobosa, Rocio Gamez-Montano
\nAn ultrasound accelerated, environmentally benign Ugi-azide based method was developed for the synthesis of 1,5-disubstituted tetrazoles under solvent and catalyst-free conditions.<\/div>\n<\/div>\n
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Endogenous water-triggered and ultrasound accelerated synthesis of 1,5-disubstituted tetrazoles via<\/em> a solvent and catalyst-free Ugi-azide reaction<\/h2>\n<\/div>\n\n
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Shrikant G. Pharande<\/a>,^{a<\/sup>\u00a0\u00a0<\/span>}Alma Rosa Corrales Escobosa<\/a>^{a<\/sup>\u00a0and\u00a0\u00a0<\/span>}Roc\u00edo G\u00e1mez-Monta\u00f1o<\/a>*^{a<\/sup>\u00a0\u00a0<\/span><\/div>\n}
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\u00a0*Corresponding authors<\/div>\n
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^{a<\/sup>Departamento de Qu\u00edmica, Divisi\u00f3n de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S\/N, Col. Noria Alta, Guanajuato, M\u00e9xico
\nE-mail: <\/b>}rociogm@ugto.mx<\/a><\/div>\n<\/div>\n<\/div>\n
Green Chem.<\/strong><\/i>, 2017, Advance Article<\/div>\nDOI: <\/strong>10.1039\/C6GC03324E, \u00a0http:\/\/pubs.rsc.org\/en\/Content\/ArticleLanding\/2017\/GC\/C6GC03324E?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract<\/a><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n
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A novel, sustainable, endogenous water-triggered, environmentally friendly, high substrate scope, efficient, solvent-free and catalyst-free Ugi-azide based method for the synthesis of 1,5-disubstituted tetrazoles is described.<\/div>\n
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$\"Shrikant$ <\/p>\n
Shrikant Pharande<\/a><\/h1>\n
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Doctoral student<\/div>\n<\/div>\n<\/div>\n
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Universidad de Guanajuato<\/a>, Guanajuato \u00b7 Department of Chemistry<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n
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Research experience<\/h2>\n
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Apr 2014\u2013Jun 2014,\u00a0Research chemist<\/div>\n
TCG Lifesciences \u00b7 pune<\/div>\n<\/li>\n
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Mar 2012\u2013Dec 2013,\u00a0project assistant<\/div>\n
CSIR – National Chemical Laboratory, Pune \u00b7 Organic Chemistry Division (NCL)<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n
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N-((1-(tert-butyl)-1H-tetrazol-5-yl)(4-chlorophenyl)methyl)aniline (4a)<\/div>\n
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Based on GP, 100 mg 4-Chlorobenzaldehyde (0.71 mmol), 0.065 cm3 aniline (0.71 mmol), 0.080 cm3 ter. Butyl isocyanide (0.71 mmol), and 0.093 cm3 TMS-azide (0.71 mmol) were reacted together to afford 237 mg (97%) as a white solid.<\/div>\n
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Melting range 144-145oC,<\/div>\n
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Rf = 0.45 (Hexane-AcOEt = 7\/3 V\/V),<\/div>\n
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1H NMR (500 MHz, CDCl3) \u03b4 7.34 \u2013 7.29 (m, 4H), 7.18 \u2013 7.13 (m, 2H), 6.79 \u2013 6.75 (m, 1H), 6.65 (d, J = 7.6 Hz, 2H), 6.11 (d, J = 6.2 Hz, 1H), 4.78 (d, J = 5.6 Hz, 1H), 1.71 (s, 9H);<\/div>\n
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13C NMR (126 MHz, CDCl3) \u03b4 155.03, 145.54, 136.81, 134.71, 129.62, 129.43, 129.19, 119.64, 114.42, 61.95, 53.93, 30.29;<\/div>\n
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FT-IR (ATR) \u03bdmax\/cm-1 3330.5, 3052.5, 2940.9, 1603.6, 1284.1;<\/div>\n
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HRMS (ESI+): m\/z calcd. for C18H20ClN5 + 342.1480, found 342.1474<\/div>\n
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\/\/\/\/\/\/\/<\/a>\/\/\/\/\/\/\/<\/p>\n","protected":false},"excerpt":{"rendered":"
Originally posted on ORGANIC CHEMISTRY SELECT: ? Endogenous water-triggered and ultrasound accelerated synthesis of 1,5-disubstituted tetrazoles via a solvent and catalyst-free Ugi-azide reaction Green Chem., 2017, Advance Article DOI: 10.1039\/C6GC03324E, Communication Shrikant G. Pharande, Alma Rosa Corrales Escobosa, Rocio Gamez-Montano An ultrasound accelerated, environmentally benign Ugi-azide based method was developed for the synthesis of\u00a01,5-disubstituted\u2026 Endogenous… Continue reading Endogenous water-triggered and ultrasound accelerated synthesis of 1,5-disubstituted tetrazoles via a solvent and catalyst-free Ugi-azide reaction<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1287"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=1287"}],"version-history":[{"count":0,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1287\/revisions"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=1287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=1287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=1287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Research experience<\/h2>\n\n\nApr 2014\u2013Jun 2014,\u00a0Research chemist<\/div>\nTCG Lifesciences \u00b7 pune<\/div>\n<\/li>\n