$\"File:Triptolide.png\"$ <\/p>\n

Triptolide<\/strong>\u00a0is a\u00a0diterpenoid<\/a>\u00a0 epoxide<\/a>\u00a0found in the Thunder God Vine,\u00a0Tripterygium wilfordii<\/a><\/em>. It has\u00a0in vitro<\/a><\/em>\u00a0and\u00a0in vivo<\/a><\/em>\u00a0activities against mouse models<\/a>\u00a0of\u00a0 polycystic kidney disease<\/a>[1]<\/a>\u00a0and\u00a0 http:\/\/en.wikipedia.org\/wiki\/Pancreatic_cancer&#8221<\/a>; rel=\u201dnofollow\u201d>pancreatic cancer, but its\u00a0 physical properties<\/a>\u00a0limit its therapeutic potential.[2]<\/a>\u00a0Consequently, a synthetic\u00a0 prodrug<\/a>,\u00a0 minnelide<\/a>, is being studied clinically<\/a>\u00a0instead.[2]<\/a><\/p>\n

A little-known plant with a truly bizarre name is now making headlines as a cancer killer, with the compound of the plant vanishing tumors in mice with pancreatic cancer. Known as the \u2018thunder god vine\u2019 or lei gong teng, the Chinese plant is actually integrated into Chinese medicine and has been used for ages in remedying a number of conditions including rheumatoid arthritis.<\/p>\n

According to the new research out of the University of Minnesota\u2019s Masonic Cancer Center, the thunder god plant compound led to no signs of tumors after a 40 day period \u2014 even after discontinuing the treatment. Published in the\u00a0journal\u00a0Science Translational Medicine<\/a><\/em><\/p>\n

http:\/\/stm.sciencemag.org\/content\/4\/156\/156ps21.full?sid=5203733d-ae1d-438e-9d36-b8bd9f16cd8d<\/a><\/p>\n

Pancreas Cancer Meets the Thunder God<\/p>\n

\n
Sunil R. Hingorani and<\/li>\n
John D. Potter<\/li>\n<\/ul>\n
Sci Transl Med 17 October 2012 4:156ps21. DOI:10.1126\/scitranslmed.3004956<\/a><\/cite><\/p>\n
\u2026minnelide) of a natural product (triptolide) that has been shown to have potent\u2026rheumatoid arthritis patients ( 4 ). Triptolide, a diterpenoid triepoxide, was first\u2026show an excess of lymphomas) ( 9 ). Triptolide inhibits proliferation and\/or induces\u2026<\/div>\n
http:\/\/stm.sciencemag.org\/content\/4\/156\/156ra139.abstract?sid=5203733d-ae1d-438e-9d36-b8bd9f16cd8d<\/a><\/div>\n
Pancreatic Cancer A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer <\/p>\n
\n
Rohit Chugh,et al<\/li>\n<\/ul>\n
Sci Transl Med 17 October 2012 4:156ra139. DOI:10.1126\/scitranslmed.3004334<\/a><\/cite><\/p>\n
\u2026characterized. One component of T. wilfordii, triptolide, has shown promising effects against\u2026malignancies-are desperately needed, but triptolide is poorly soluble in water and thus\u2026synthesize a water-soluble form of triptolide, Minnelide, and demonstrate efficacy\u2026<\/div>\n<\/div>\n
and funded by the National Institutes of Health, even the scientists working on the project were stunned by the anti-cancer properties of the compound. Known to contain something known as\u00a0triptolide, which has been identified as a cancer fighter in previous research, it is thought to be the key component that may be responsible for the anti-tumor capabilities.<\/p>\n
$\u201dChinese$ http:\/\/thearrowsoftruth.com\/wp-content\/uploads\/2012\/10\/thunder-god-vine-stalk_medium-300\u00d7199.jpg” width=\u201d300\u2033 height=\u201d199\u2033 \/><\/p>\n
And just like with numerous other powerful substances like turmeric and ginger, mainstream science is still slowly confirming what many traditional practitioners\u00a0have known for their entire lives. This is, of course, due to the fact that\u00a0there is simply no money<\/strong>for major corporations in researching the healing powers of natural herbs and compounds such as the compound found in the thunder god vine. Turmeric and ginger, for example, have been found to be amazing anti-cancer substances that are virtually free compared to expensive and dangerous cancer drugs.<\/p>\n
References<\/h2>\n\n
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Leuenroth, Stephanie (2007).\u00a0<\/a>\u201cTriptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease\u201d<\/a>.PNAS<\/em>104<\/strong>\u00a0(11): 4389-4394.\u00a0doi<\/a>:10.1073\/pnas.0700499104<\/a>. Retrieved 18 October 2012.<\/li>\n
Chugh, Rohit (2012).\u00a0 \u201cA Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer\u201d<\/a>.\u00a0Science Translational Medicine<\/em>4<\/strong>\u00a0(156): 156ra139.\u00a0doi<\/a>:10.1126\/scitranslmed.3004334<\/a>. Retrieved 18 October 2012.<\/li>\n<\/ol>\n<\/div>\n
$\"Triptolide\"$ <\/a><\/div>\n
http:\/\/www.nature.com\/nchembio\/journal\/v7\/n3\/abs\/nchembio.522.html<\/a><\/div>\n
Triptolide (1<\/a>) is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. Its molecular mechanism of action, however, has remained largely elusive to date. We report that triptolide covalently binds to human XPB (also known as ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II\u2013mediated transcription and likely nucleotide excision repair. The identification of XPB as the target of triptolide accounts for the majority of the known biological activities of triptolide. These findings also suggest that triptolide can serve as a new molecular probe for studying transcription and, potentially, as a new type of anticancer agent through inhibition of the ATPase activity of XPB.<\/div>\n
\u2018If you liked this post, say thanks by sharing it or mail me amcrasto@gmail.com, all content is academic.<\/div>\n","protected":false},"excerpt":{"rendered":"
Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research. Triptolide\u00a0is a\u00a0diterpenoid\u00a0epoxide\u00a0found in the Thunder God Vine,\u00a0Tripterygium wilfordii. It has\u00a0in vitro\u00a0and\u00a0in vivo\u00a0activities againstmouse models\u00a0of\u00a0polycystic kidney disease[1]\u00a0and\u00a0http:\/\/en.wikipedia.org\/wiki\/Pancreatic_cancer” rel=\u201dnofollow\u201d>pancreatic cancer, but its\u00a0physical properties\u00a0limit its therapeutic potential.[2]\u00a0Consequently, a synthetic\u00a0prodrug,\u00a0minnelide, is being studiedclinically\u00a0instead.[2] A little-known plant with a truly bizarre name is now making headlines… Continue reading Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research.<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[137,145,134,91,135,136],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1267"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=1267"}],"version-history":[{"count":1,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1267\/revisions"}],"predecessor-version":[{"id":1268,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1267\/revisions\/1268"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=1267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=1267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=1267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research.<\/a><\/h2>\n<\/div>\n<\/p>\n