<\/a> $\"Abstract$ <\/div>\n

The\u00a0N<\/i>-methylation of electron-deficient pyrroles was affected using dimethyl carbonate in the presence of DMF and catalytic DABCO. This alkylation methodology has proven useful for the alkylation of a variety of pyrroles in 72\u221298% yields and is considered to be\u00a0greenchemistry relative to the more common use of methyl halides or dimethyl sulfate.<\/p>\n<\/div>\n

<\/div>\nMichael L. Laurila<\/a>\u00a0,\u00a0 Nicholas A. Magnus<\/a>\u00a0 *<\/a>\u00a0and Michael A. Staszak<\/a>\u00a0 *<\/a><\/div>\n
Eli Lilly and Company, Chemical Product Research and Development Division, Indianapolis, Indiana 46285, U.S.A<\/div>\n
Org. Process Res. Dev.<\/cite>,\u00a02009,\u00a013\u00a0(6), pp 1199\u20131201<\/div>\n
DOI:\u00a0<\/strong>10.1021\/op900256t<\/div>\nPublication Date (Web): October 26, 2009<\/div>\n
http:\/\/pubs.acs.org\/doi\/full\/10.1021\/op900256t?prevSearch=GREEN%2BSOLVENTS&searchHistoryKey=<\/a><\/div>\n
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Herein, the\u00a0N<\/i>-methylation of compound\u00a01<\/b>\u00a0along with a number of commercially available pyrrole derivatives using DMC, DMF and catalytic 1,4-diazabicyclo[2.2.2]octane (DABCO) are described.<\/div>\n
<\/div>\n","protected":false},"excerpt":{"rendered":"
The\u00a0N-methylation of electron-deficient pyrroles was affected using dimethyl carbonate in the presence of DMF and catalytic DABCO. This alkylation methodology has proven useful for the alkylation of a variety of pyrroles in 72\u221298% yields and is considered to be\u00a0greenchemistry relative to the more common use of methyl halides or dimethyl sulfate. Michael L. Laurila\u00a0,\u00a0Nicholas A.… Continue reading Green N-Methylation of Electron Deficient Pyrroles with Dimethylcarbonate<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[18,146,99,11,143,55],"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1183"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=1183"}],"version-history":[{"count":1,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1183\/revisions"}],"predecessor-version":[{"id":1184,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/posts\/1183\/revisions\/1184"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=1183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/categories?post=1183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/tags?post=1183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}