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The \u03b1-tocopherol form of vitamin E $\"\"$ <\/p>\n

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Vitamin E<\/strong> refers to a group of eight fat-soluble compounds that include both tocopherolsand tocotrienols.^{[1]<\/sup> There are many different forms of vitamin E, of which \u03b3-tocopherol is the most common in the North American diet.^{[2]<\/sup> \u03b3-Tocopherol can be found in corn oil, soybean oil, margarine and dressings.^{[3]<\/sup>^{[4]<\/sup> In the North American diet, \u03b1-Tocopherol, the most biologically active form of vitamin E, is the second most common form of vitamin E. This variant of vitamin E can be found most abundantly in wheat germ oil, sunflower, and safflower oils.^{[4]<\/sup>^{[5]<\/sup> It is a fat-soluble}}}}}}antioxidant<\/a> that stops the production of reactive oxygen species formed when fat undergoes oxidation.^{[6]<\/sup>^{[7]<\/sup>^{[8]<\/sup><\/p>\n}}}

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Synthesis of Vitamin E<\/li>\n<\/ul>\n
Vitamin E (CAS NO.: 59-02-9), with other names as 2(R),5,7,8-Tetramethyl-2-[4(R),8(R),12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol, could be produced through the following synthetic routes. $\"Dictionary\"$ <\/a>,<\/p>\n
$\"Synthesis$ <\/div>\n
$\"Synthesis$ <\/div>\n
The chlorination of myrcene (I) with Cl_{2<\/sub> in refluxing pentane gives the choromyrcene (II), and the hydrochlorination of (I) catalyzed by CuCl yields a mixture of geranyl\/neryl chloride (III). The reductive coupling of (II) and (III) by means of Mg and CuCl affords beta-springene (IV), which is condensed with 2,3,6-trimethylhydroquinone (V) by means of cyclooctadienyl rhodium chloride dimer [RhCl(COD)]_{2<\/sub> and K_{2<\/sub>CO_{3<\/sub> in refluxing toluene to provide the adduct (VI). The cyclization of (VI) by means of MeAlCl_{2<\/sub> of Ts-OH in refluxing hexane furnishes the tocotrienol (VII), which is finally hydrogenated with H_{2<\/sub> over Pd\/C in ethanol to give the target (rac)-vitamin E.<\/div>\n}}}}}}
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<\/h2>\n
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$\"Links\"$ References<\/h2>\n
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Brigelius-Flohe, B; Traber (1999). “Vitamin E: function and metabolism”. FASEB<\/em> 13<\/strong>: 1145\u20131155.<\/li>\n
Traber, MG (1998). “The biological activity of vitamin E”<\/a>. The Linus Pauling Institute. Retrieved 6 March 2011.<\/li>\n
Bieri, JG; Evarts (1974). “\u03b3-Tocopherol: metabolism, biological activity and significance in human vitamin E nutrition”. American Journal of Clinical Nutrition<\/em> 27<\/strong> (9): 980\u2013986. PMID<\/a> 4472121<\/a>.<\/li>\n
Brigelius-Floh\u00e9 R, Traber MG (1 July 1999). “Vitamin E: function and metabolism”. FASEB J.<\/em> 13<\/strong> (10): 1145\u201355. PMID<\/a> 10385606<\/a>.<\/li>\n
Reboul E, Richelle M, Perrot E, Desmoulins-Malezet C, Pirisi V, Borel P (15 November 2006). “Bioaccessibility of carotenoids and vitamin E from their main dietary sources”. Journal of Agricultural and Food Chemistry<\/em> 54<\/strong> (23): 8749\u20138755. doi<\/a>:10.1021\/jf061818s<\/a>.PMID<\/a> 17090117<\/a>.<\/li>\n
National Institute of Health (4 May 2009). “Vitamin E fact sheet”<\/a>.<\/li>\n
Herrera; Barbas, C (2001). “Vitamin E: action, metabolism and perspectives”. Journal of Physiology and Biochemistry<\/em> 57<\/strong> (2): 43\u201356.doi<\/a>:10.1007\/BF03179812<\/a>. PMID<\/a> 11579997<\/a>.<\/li>\n
Packer L, Weber SU, Rimbach G (2001). “Molecular aspects of \u03b1-tocotrienol antioxidant action and cell signalling”<\/a>. Journal of Nutrition<\/em> 131<\/strong> (2): 369S\u201373S. PMID<\/a> 11160563<\/a>.<\/li>\n<\/ol>\n
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Vitamin E bound to proteins<\/a> in the PDB<\/a><\/li>\n
Vitamin E<\/a> Medline Plus, Medical Encyclopedia, U.S. National Library of Medicine<\/li>\n
Vitamin E<\/a> Office of Dietary Supplements, National Institutes of Health<\/li>\n
Jane Higdon, “Vitamin E<\/a>“, Micronutrient Information Center, Linus Pauling Institute<\/a>, Oregon State University<\/a><\/em><\/li>\n
Vitamin E Food Charts<\/a><\/li>\n<\/ul>\n
DR ANTHONY MELVIN CRASTO Ph.D<\/p>\n
$\"ANTHONY$ <\/p>\n
amcrasto@gmail.com<\/a><\/p>\n
MOBILE-+91 9323115463<\/div>\n
GLENMARK SCIENTIST , NAVIMUMBAI, INDIA<\/div>\n
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DR ANTHONY CRASTO, PhD, ICT Organic chemistry, Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) at Mahape, Navi Mumbai, India, helping millions, million hits on google on all organic chemistry websites, Hands on experience in developing novel routes for drug molecules and implementation on commercial scale. several international patents published.pushing boundaries, one lakh connections on all networking sites<\/h2>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
Vitamin E The \u03b1-tocopherol form of vitamin E Vitamin E refers to a group of eight fat-soluble compounds that include both tocopherolsand tocotrienols.[1] There are many different forms of vitamin E, of which \u03b3-tocopherol is the most common in the North American diet.[2] \u03b3-Tocopherol can be found in corn oil, soybean oil, margarine and dressings.[3][4]… Continue reading Drug basics<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/pages\/907"}],"collection":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/comments?post=907"}],"version-history":[{"count":1,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/pages\/907\/revisions"}],"predecessor-version":[{"id":908,"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/pages\/907\/revisions\/908"}],"wp:attachment":[{"href":"https:\/\/amcrasto.theeurekamoments.com\/wp-json\/wp\/v2\/media?parent=907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}