Category Archives: SYNTHESIS

The Magic of Cubane!

  Cubane[1] Pentacyclo[4.2.0.02,5.03,8.04,7]octane CAS 277-10-1 Cubane (C8H8) is a synthetic hydrocarbon molecule that consists of eight carbon atoms arranged at the corners of a cube, with one hydrogen atom attached to each carbon atom. A solid crystalline substance, cubane is one of the Platonic hydrocarbons. It was first synthesized in 1964 by Philip Eaton, … Continue reading

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Synthesis of Azadirachtin

Azadirachtin 11141-17-6  cas no Azadirachtin, a chemical compound belonging to the limonoid group, is asecondary metabolite present in neem seeds. It is a highly oxidizedtetranortriterpenoid which boasts a plethora of oxygen functionality, comprising an enol ether, acetal, hemiacetal, and tetra-substituted oxirane as well as a variety of carboxylic esters. This compound is a … Continue reading

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Whisky lactone

Whisky Lactone Whisky lactone, also known as β-methyl-γ-octalactone or quercus lactone (from the Latin for oak treeQuercus alba), is a flavouring found in American bourbon whiskies, and is also found in all types of oak. The flavour gets into the whisky when … Continue reading

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Amide Hydrogenation in Flow Reactor

http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html Amide Hydrogenation in Flow Reactor (wiley) Amines are produced by amide hydrogenation over a bimetallic platinum–rhenium catalyst in a high-throughput vertical flow reactor Read more http://www.chemistryviews.org/details/ezine/5392681/Amide_Hydrogenation_in_Flow_Reactor.html Share this:

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Transition-metal-catalyzed C–C bond formation through the fixation ofcarbon dioxide

Carbon dioxide is an important carbon source in the atmosphere and is “problematic” toward the activities of human beings. Although carbon dioxide is a cheap, abundant and relatively nontoxic C1 source, its chemical transformations have not been widely developed so … Continue reading

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GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

Green Chem., 2013, Advance Article DOI: 10.1039/C3GC41799A, Communication Huiyan Wang, Xuecheng Liu, Xian Feng, Zhibin Huang, Daqing Shi This synthesis was confirmed to follow the GAP chemistry process, which can avoid traditional chromatography and recrystallization purification methods. GAP chemistry for … Continue reading

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Lewis acid-surfactant-combined catalyzed synthesis of 4-aminocyclopentenones from glycals in water

Green Chem., 2013, 15,3180-3183 DOI: 10.1039/C3GC41032C, Communication Siming Wang, Ronny William, Kim Kui Georgina Estelle Seah, Xue-Wei Liu Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 Water makes the … Continue reading

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Axial-to-central chirality transfer in cyclization processes

Axial-to-central chirality transfer in cyclization processes Substrates, bearing axial chirality, can cyclize intra- or inter-molecularly with concomitant transfer of axial-to-central chirality to produce at least one stereocenter. In order to satisfy a strict definition of axial-to-central chirality transfer, the initial … Continue reading

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An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature

An efficient palladium catalyst on bentonite for Suzuki-Miyaura reaction at room temperature Green Chem., 2013, Advance Article DOI: 10.1039/C3GC41469H, Paper Guodong Ding, Weitao Wang, Tao Jiang, Buxing Han The Pd/bentonite catalyst prepared by a simple impregnation method in water is … Continue reading

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Seeding removes barrier to curious cocrystal

Once the heteronuclear seeds had been used in the lab, the cocrystal formed regardless of whether or not the seeds were used The caffeine•benzoic acid cocrystal that has eluded scientists for 60 years has finally been crystallised Cocrystals are crystalline … Continue reading

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