Author: DR ANTHONY MELVIN CRASTO Ph.D

Deflazacort CAS 14484-47-0 Molecular Formula C25H31NO6 Average mass 441.517 Da (11b,16b)-21-(Acetyloxy)-11-hydroxy-2′-methyl-5’H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 11b,21-Dihydroxy-2′-methyl-5’bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate 2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2′,1′:4,5]indeno[1,2-d][1,3]oxazol-6b-yl]-2-oxoethyl acetate 5’βH-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11β,21-dihydroxy-2′-methyl-, 21-acetate (8CI) (11β,16β)-21-(Acetyloxy)-11-hydroxy-2′-methyl-5’H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 2H-Naphth[2′,1′:4,5]indeno[1,2-d]oxazole, 5’H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione deriv. Azacort Azacortinol Calcort DL 458IT Deflan Optical Rotatory Power +62.3 ° Conc: 0.5 g/100mL; Solv: chloroform (67-66-3); Wavlength: 589.3 nm …………..REF, “Drugs – Synonyms and Properties” data were obtained from Ashgate Publishing… Continue reading DEFLAZACORT

Pridopidine OXIDE Example 5 – Preparation Of Compound 5 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidine 1-oxide) Pridopidine (50.0g, 178mmol, leq) was dissolved in methanol (250mL) and 33% hydrogen peroxide (20mL, 213mmol, 1.2eq). The reaction mixture was heated and kept at 40°C for 20h. The reaction mixture was then concentrated in a rotavapor to give 71g light-yellow oil. Water (400mL) was… via… Continue reading PRIDOPIDINE OXIDE

MK 0633, SETILEUTON (-)-enantiomer 910656-27-8 CAS free form MW 463.3817, C22 H17 F4 N3 O4 FREE FORM Tosylate cas 1137737-87-1 2H-1-Benzopyran-2-one, 4-(4-fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]- 4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one WO2006099735A1 Inventors Thiadiazole substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitor WO 2006099735 A1Marc Blouin, Erich L. Grimm, Yves Gareau, Marc Gagnon, Helene Juteau, Sebastien Laliberte, Bruce Mackay, Richard Friesen,… Continue reading SETILEUTON, MK 0633

Originally posted on ORGANIC CHEMISTRY SELECT: Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts Green Chem., 2017, 19,809-815 DOI: 10.1039/C6GC03141B, Paper Haigen Huang, Xueguang Wang, Xu Li, Chenju Chen, Xiujing Zou, Weizhong Ding, Xionggang Lu A non-noble Ni-MoO3/CN@SBA-15 catalyst exhibits unprecedented catalytic activity and chemoselectivity for the reduction of nitroarenes to anilines… via… Continue reading Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts

Originally posted on Green Chemistry International: Fig. 3 Stereoselectivities of the new ApPDC-variants for the synthesis of (S)-PAC. The different variants were tested as wet cells, crude cell extracts, and purified enzymes. Reaction conditions: wet cells – 20 mM benzaldehyde; 200 mM pyruvate; 50 mM KPi-buffer (pH 6.5), 2.5 mM MgSO4; 0.1 mM ThDP; 20… via… Continue reading Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation

Originally posted on ORGANIC CHEMISTRY SELECT: ? Endogenous water-triggered and ultrasound accelerated synthesis of 1,5-disubstituted tetrazoles via a solvent and catalyst-free Ugi-azide reaction Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03324E, Communication Shrikant G. Pharande, Alma Rosa Corrales Escobosa, Rocio Gamez-Montano An ultrasound accelerated, environmentally benign Ugi-azide based method was developed for the synthesis of 1,5-disubstituted… Endogenous… Continue reading Endogenous water-triggered and ultrasound accelerated synthesis of 1,5-disubstituted tetrazoles via a solvent and catalyst-free Ugi-azide reaction

Pd/Cu-free Heck and Sonogashira cross-coupling reaction by Co nanoparticles immobilized on magnetic chitosan as reusable catalyst Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03377F, Paper Abdol R. Hajipour, Fatemeh Rezaei, Zahra Khorsandi Chitosan (CS) is a porous, self-standing, nanofibrillar microsphere that can be used as a metal carrier. Amino groups on CS enable to modulate cobalt… Continue reading Pd/Cu-free Heck and Sonogashira cross-coupling reaction by Co nanoparticles immobilized on magnetic chitosan as reusable catalyst