http://www.intechopen.com/books/stem-cells-in-clinic-and-research
Stem Cells in Clinic and Research
Edited by Ali Gholamrezanezhad, ISBN 978-953-307-797-0, Hard cover, 804 pages, Publisher: InTech, Chapters published August 23, 2011 under CC BY-NC-SA 3.0 license
DOI: 10.5772/740
Based on our current understanding of cell biology and strong supporting evidence from previous experiences, different types of human stem cell populations are capable of undergoing differentiation or trans-differentiation into functionally and biologically active cells for use in therapeutic purposes. So far, progress regarding the use of both in vitro and in vivo regenerative medicine models already offers hope for the application of different types of stem cells as a powerful new therapeutic option to treat different diseases that were previously considered to be untreatable. Remarkable achievements in cell biology resulting in the isolation and characterization of various stem cells and progenitor cells has increased the expectation for the development of a new approach to the treatment of genetic and developmental human diseases. Due to the fact that currently stem cells and umbilical cord banks are so strictly defined and available, it seems that this mission is investigationally more practical than in the past. On the other hand, studies performed on stem cells, targeting their conversion into functionally mature tissue, are not necessarily seeking to result in the clinical application of the differentiated cells; In fact, still one of the important goals of these studies is to get acquainted with the natural process of development of mature cells from their immature progenitors during the embryonic period onwards, which can produce valuable results as knowledge of the developmental processes during embryogenesis. For example, the cellular and molecular mechanisms leading to mature and adult cells developmental abnormalities are relatively unknown. This lack of understanding stems from the lack of a good model system to study cell development and differentiation. Hence, the knowledge reached through these studies can prove to be a breakthrough in preventing developmental disorders. Meanwhile, many researchers conduct these studies to understand the molecular and cellular basis of cancer development. The fact that cancer is one of the leading causes of death throughout the world, highlights the importance of these researches in the fields of biology and medicine.
Chapter 1 Stem Cells: General Features and Characteristicsby Hongxiang Hui, Yongming Tang, Min Hu and Xiaoning Zhao
- Chapter 2 Human Cord Blood-Derived Stem Cells in Transplantation and Regenerative Medicineby Cornel Iancu, Ioana Ilie, Lucian Mocan, Carmen Georgescu, Razvan Ilie, Ileana Duncea, Teodora Mocan, Dana Iancu, and Florin Zaharie
- Chapter 3 Mesenchymal Stem Cells: Immunology and Therapeutic Benefitsby Najib El Haddad
- Chapter 4 How do Mesenchymal Stem Cells Repair?by Patricia Semedo, Marina Burgos-Silva, Cassiano Donizetti-Oliveira and Niels Olsen Saraiva Camara
- Chapter 5 Immunogenicity and Immune-Modulating Properties of Human Stem Cellsby Jan Nehlin, Adiba Isa and Torben Barington
- Chapter 6 Stem Cell Culture Collection – Promising Strategy for Animal Genetic Resource Preservationby Weijun Guan, Xiangchen Li, Dapeng Jin, Xiaohong He, Yabin Pu, Qianjun Zhao, Taofeng Lu, Chunyu Bai, Shen Wu, Xiaohua Su and Yuehui Ma
- Chapter 7 The Role of SOX2 in Maintaining Pluripotency and Differentiation of Human Embryonic Stem Cellsby Keiko Adachi, Hirofumi Suemori, Norio Nakatsuji and Eihachiro Kawase
- Chapter 8 The Role of MicroRNAs in Regulating Cancer Stem Cellsby Musaffe Tuna and Christopher I. Amos
- Chapter 9 Are We There Yet? A Story About Cardiac Stem Cellsby Shizuka Uchida, Piera De Gaspari and Thomas Braun
- Chapter 10 Stem Cell Therapy in Myocardial Infarction Clinical Point of View and the Results of the REANIMA Study (REgenerAtion of Myocardium with boNe Marrow Mononuclear Cells in MyocArdial Infarction)by Slobodan Obradovic, Bela Balint and Zoran Trifunovic
- Chapter 11 Randomized Clinical Trials in Stem Cell Therapy for the Heart – Old and New Types of Cells for Cardiovascular Repairby Ricardo Sanz-Ruiz, Adolfo Villa Arranz, Enrique Gutiérrez Ibañes, María Eugenia Fernández Santos, Pedro Luis Sánchez Fernández and Francisco Fernández-Avilés
- Chapter 12 Autologous Stem Cells for Cardiac Repair: New Insights on Clinical Trial Safety and Best Cell Sourceby Nicolas Noiseux, Louis Mathieu Stevens, Jessica Forcillo and Samer Mansour
- Chapter 13 Stem Cell Transplantation for the Treatment of Peripheral Arterial Diseaseby Nikolaos Papanas
- Chapter 14 Myogenic Potential of Murine Embryonic Stem Cells in the Dmdmdx Mouse Model for Duchenne Muscular Dystrophyby Danielle Ayub-Guerrieri, Poliana C. M. Martins-Machado, Paula C.G. Onofre-Oliveira, Lygia V. Pereira, Camila F. Almeida, Vanessa F. Lopes and Mariz Vainzof
- Chapter 15 Stem Cell in Neurological Disordersby Nirmeen Kishk and Noha Abokrysha
- Chapter 16 Cell Therapy for Parkinson’s Disease: Failure or Success?by Magdalena Guerra-Crespo, Alberto K. De la Herrán-Arita, Arturo Hernández-Cruz, José Bargas and René Drucker-Colín
- Chapter 17 Stem Cell Therapy for Neuromuscular Diseasesby Mirella Meregalli, Andrea Farini and Yvan Torrente
- Chapter 18 Treatment of the end Stage Liver Cirrhosis by Human Umbilical Cord Blood Stem Cells: Preliminary Resultsby Jong Yoon Bahk, Zhengfu Piao, Jae Hun Jung and Hoon Han
- Chapter 19 Stem Cell Therapy for Patients with Chronic Liver Diseaseby Reebye, V; Levičar, N and Habib, N.
- Chapter 20 Pancreatic Stem Cells: Unresolved Businessby Fang-Xu Jiang and Grant Morahan
- Chapter 21 Cell Sources for Treating Diabetesby Subhshri Sahu, Mugdha V. Joglekar, Sundy N. Y. Yang and Anandwardhan A. Hardikar
- Chapter 22 Stem Cell Therapy for Islet Regenerationby Phuc Pham Van
- Chapter 23 Topical Stem and Progenitor Cell Therapy for Diabetic Foot Ulcersby Aonghus O’Loughlin and Timothy O’Brien
- Chapter 24 Regeneration of the Kidney – Viewed from ES Cellby Hirotsugu Iwatani and Enyu Imai
- Chapter 25 Periodontal Ligament Stem Cellsby Hidefumi Maeda, Naohisa Wada, Shinsuke Fujii, Atsushi Tomokiyo and Akifumi Akamine
- Chapter 26 Clinical Stem Cell Imaging and In vivo Trackingby Sahar Mirpour and Ali Gholamrezanezhad
- Chapter 27 Invasive Fungal Infections in Patients with Acute Leukemia and Hematopoietic Stem Cell Transplant Recipientsby Maxim Norkin and John R. Wingard
- Chapter 28 Synchrotron Radiation and Nanotechnology for Stem Cell Researchby Alessandra Giuliani, Fabrizio Fiori, Adrian Manescu, Vladimir S. Komlev, Chiara Renghini and Franco Rustichelli
- Chapter 29 Spontaneous Generation of Neurospheres from Mouse Embryonic Stem Cellsby Roberto Di Maio, Kommu Naga Mohan, Brianna Heath and Leonardo D’Aiuto
- Chapter 30 Multidrug Resistance Transporters – Roles in maintaining Cancer Stem-Like Cellsby To, Kenneth K.W. and Fu, L.W.
- Chapter 31 Associated Adeno Virus Vector for Producing Induced Pluripotent Stem Cells (IPS) for Human Somatic Cellsby Edilamar Menezes Oliveira and M Ian Phillips
- Chapter 32 Raman Spectroscopy for Noninvasive Monitoring of Umbilical Cord Mesenchymal Stem Cells Viability Transitionsby P.Chen, F.Zhang, L.Lin, H.Bai, L.Zhang, G.Q.Tang, H.Fang, G.G.Mu, W. Gong, Z. P. Liu, Z. B. Han, H. Zhao and Z. C. Han
- Chapter 33 Novel Platforms to Create Labeled Stem Cellsby Andrew Fontes, Rene Quintanilla and Uma Lakshmipathy