L-citrulline, reduces muscle fatigue

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The organic compound citrulline is an α-amino acid. Its name is derived from citrullus, theLatin word for watermelon, from which it was first isolated in 1914 by Koga & Odake. It was finally identified by Wada in 1930.[2] It has the idealized formulaH2NC(O)NH(CH2)3CH(NH2)CO2H. It is a key intermediate in the urea cycle, the pathway by which mammals excrete ammonia.

Although human 
DNA does not code for citrulline directly, several proteins contain citrulline as a result of a posttranslational modification. These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histoneproteins, whereas other proteins, such as fibrin and vimentin are susceptible to citrullination during cell death and tissue inflammation.Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family (NOS; EC[3] It is made from arginine by the enzymetrichohyalin at the inner root sheath and medulla of hair follicles.[4] Arginine is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.

Patients with rheumatoid arthritis often have detectable antibodies against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline (anti-citrullinated protein antibodies) containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.[5]

In recent studies, citrulline has been found to relax blood vessels.[6] Circulating citrulline concentration is, in humans, a biomarker of intestinal functionality.[7]

Citrulline in the form of citrulline malate is sold as a performance-enhancing athletic dietary supplement, which was shown to reduce muscle fatigue in a preliminary clinical trial.[8]

The rind of watermelon (Citrullus lanatus) is a good natural source of citrulline.[9]

  1.  “Citrulline – Compound Summary”PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. Identification. Retrieved 1 May 2012.
  2.  Fearon, William Robert (1939). “The Carbamido Diacetyl Reaction: A Test For Citrulline”Biochemical Journal 33 (6): 902–907.
  3. ^ Cox M, Lehninger AL, Nelson DR (2000). Lehninger principles of biochemistry (3rd ed.). New York: Worth Publishers. ISBN 1-57259-153-6.
  4.  Rogers, G. E.; Rothnagel, J. A. (1983). “A sensitive assay for the enzyme activity in hair follicles and epidermis that catalyses the peptidyl-arginine-citrulline post-translational modification”. Current problems in dermatology 11: 171–184. PMID 6653155edit
  5.  Coenen D, Verschueren P, Westhovens R, Bossuyt X (March 2007). “Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis”Clin. Chem. 53 (3): 498–504.doi:10.1373/clinchem.2006.078063PMID 17259232.
  6.  Viagra-Like Effects From Watermelon
  7.  Crenn P. et al. Post-absorptive plasma citrulline concentration is a marker of intestinal failure in short bowel syndrome patients. Gastroenterology 119 (2000) , 1496-505
  8.  Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ (Aug 2002). “Citrulline/malate promotes aerobic energy production in human exercising muscle”Br J Sports Med 36 (4): 282–9. doi:10.1136/bjsm.36.4.282PMC 1724533.PMID 12145119.
  9.  Watermelon May Have Viagra-effect


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  1. Pingback: Watermelon Juice Prevents Aching Muscles « New Drug Approvals

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