Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research.

File:Triptolide.png

Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii. It has in vitro and in vivo activities against mouse models of polycystic kidney disease[1] and pancreatic cancer, but its physical properties limit its therapeutic potential.[2] Consequently, a synthetic prodrug, minnelide, is being studied clinically instead.[2]

A little-known plant with a truly bizarre name is now making headlines as a cancer killer, with the compound of the plant vanishing tumors in mice with pancreatic cancer. Known as the ‘thunder god vine’ or lei gong teng, the Chinese plant is actually integrated into Chinese medicine and has been used for ages in remedying a number of conditions including rheumatoid arthritis.

According to the new research out of the University of Minnesota’s Masonic Cancer Center, the thunder god plant compound led to no signs of tumors after a 40 day period — even after discontinuing the treatment. Published in the journal Science Translational Medicine

http://stm.sciencemag.org/content/4/156/156ps21.full?sid=5203733d-ae1d-438e-9d36-b8bd9f16cd8d

Pancreas Cancer Meets the Thunder God

  • Sunil R. Hingorani and
  • John D. Potter

Sci Transl Med 17 October 2012 4:156ps21. DOI:10.1126/scitranslmed.3004956

…minnelide) of a natural product (triptolide) that has been shown to have potent…rheumatoid arthritis patients ( 4 ). Triptolide, a diterpenoid triepoxide, was first…show an excess of lymphomas) ( 9 ). Triptolide inhibits proliferation and/or induces…
Pancreatic Cancer A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

  • Rohit Chugh,et al

Sci Transl Med 17 October 2012 4:156ra139. DOI:10.1126/scitranslmed.3004334

…characterized. One component of T. wilfordii, triptolide, has shown promising effects against…malignancies-are desperately needed, but triptolide is poorly soluble in water and thus…synthesize a water-soluble form of triptolide, Minnelide, and demonstrate efficacy…

and funded by the National Institutes of Health, even the scientists working on the project were stunned by the anti-cancer properties of the compound. Known to contain something known as triptolide, which has been identified as a cancer fighter in previous research, it is thought to be the key component that may be responsible for the anti-tumor capabilities.

Chinese "Thunder God Vine" or Lei Gong TengChinese “Thunder God Vine” or Lei Gong Teng

And just like with numerous other powerful substances like turmeric and ginger, mainstream science is still slowly confirming what many traditional practitioners have known for their entire lives. This is, of course, due to the fact that there is simply no moneyfor major corporations in researching the healing powers of natural herbs and compounds such as the compound found in the thunder god vine. Turmeric and ginger, for example, have been found to be amazing anti-cancer substances that are virtually free compared to expensive and dangerous cancer drugs.

References

  1. Leuenroth, Stephanie (2007). “Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease”. PNAS104 (11): 4389-4394. doi:10.1073/pnas.0700499104. Retrieved 18 October 2012.
  2. Chugh, Rohit (2012). “A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer”. Science Translational Medicine4 (156): 156ra139. doi:10.1126/scitranslmed.3004334. Retrieved 18 October 2012.
Triptolide
Triptolide (1) is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. Its molecular mechanism of action, however, has remained largely elusive to date. We report that triptolide covalently binds to human XPB (also known as ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II–mediated transcription and likely nucleotide excision repair. The identification of XPB as the target of triptolide accounts for the majority of the known biological activities of triptolide. These findings also suggest that triptolide can serve as a new molecular probe for studying transcription and, potentially, as a new type of anticancer agent through inhibition of the ATPase activity of XPB.
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3 Responses to Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research.

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  2. Mark says:

    I have a co worker that has just been diagnosed with pancreatic cancer. While I understand that the thunder vine is only been proven effective in stopping pancreatic cancer in mice is there a method to obtain it and how would you take it to possibly make this a potential option for him? It would appear there are limited other options.

  3. P Gardner says:

    Has this been tested on other cancers? Is this effective with esophageal cancer?

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