Monthly Archives: December 2012

One-Pot Synthesis of Alkyl Styryl Sulfides Free from Transition Metal/Ligand Catalyst and Thiols

One-Pot Synthesis of Alkyl Styryl Sulfides Free from Transition Metal/Ligand Catalyst and Thiols http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201201163/abstract European Journal of Organic Chemistry Early View (Online Version of Record published before inclusion in an issue) Adrián A. Heredia and Alicia B. Peñéñory Article first … Continue reading

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Total Synthesis and Structure Confirmation of Cryptocaryol A

  Total Synthesis and Structure Confirmation of Cryptocaryol A European journal of chemistryEarly View (Online Version of Record published before inclusion in an issue) D. Srinivas Reddy and Debendra K. Mohapatra Article first published online: 19 DEC 2012 | DOI: 10.1002/ejoc.201201309 … Continue reading

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Pinnick oxidation

The Pinnick oxidation is also known as Lindgren oxidation. It is an organic reaction by which aldehydes can be oxidized into its corresponding carboxylic acid, originally developed by Lindgren and Nilsson.ref1      The typical reaction condition used today was modified by G. A. Kraus even before Pinnick.ref2,3  Pinnick proved … Continue reading

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US 6894199, Process for the production of xylitol

  (2R,4S)-Pentane-1,2,3,4,5-pentol Xylitol  used to denote sugar alcohols) is a sugar alcohol sweetener used as a sugar substitute. Xylitol has the formula (CHOH)3(CH2OH)2 and is an achiral isomer of pentane-1,2,3,4,5-pentol. Xylitol is roughly as sweet as sucrose with 33% fewer calories. Unlike other sweeteners, xylitol is actively beneficial … Continue reading

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AVANAFIL, NEW DRUG FOR ERECTILE DYSFUNCTION, FDA APRIL 2012

Avanafil is a PDE5 inhibitor approved for erectile dysfunction on April 27, 2012.[1] Avanafil is known by the trademark name Stendra and was developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, … Continue reading

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New Data for Jakafi® (Ruxolitinib) to Be Presented at the 2012 American Society of Hematology Annual Meeting

Ruxolitinib (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile, CAS number 941678-49-5  Incyte Corporation (Nasdaq: INCY) announced today that several analyses from clinical studies of Jakafi® (ruxolitinib) will be presented at the 2012 American Society of Hematology (ASH) Annual Meeting from Dec. 8 to 11 , 2012 … Continue reading

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FDA accepts AVEO-Astellas tivozanib NDA filing for renal cell carcinoma, 29 nov 2012

1-{2-Chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methylisoxazol-3-yl)urea AV-951  Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor. It is undergoing clinical trial investigation for the treatment of renal cell carcinomas.[1] An oral quinoline urea derivative, tivozanib suppresses angiogenesis by being selectively inhibitory against vascular endothelial growth factor.[2] It was developed by AVEO Pharmaceuticals.[3] It is designed to inhibit … Continue reading

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