Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes

Synthesis of Chiral Pyridylphenols for the Enantioselective Addition of Diethylzinc to Aldehydes

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http://onlinelibrary.wiley.com/doi/10.1002/jccs.201100474/abstract

DOI: 10.1002/jccs.201100474

Chiral 8-substituted 2-(8,10,10-trimethyl-6-aza-tricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl)-phenols were prepared from a high enantiopurity (>97% ee) of (1R)-(+)-alpha-pinene, and assessed in the enantioselective addition of diethylzinc to substituted benzaldehydes, giving the (S)-alcohols with enantiomeric excess ranging from 33% to 89%. Interestingly, in all cases, except for those of ortho-chlorobenzaldehyde, ortho- and para-methoxybenzaldehydes, the ee was >71%.

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Journal of the Chinese Chemical Society

Volume 59, Issue 6, pages 768–781, June 2012

 

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